Parent Class:

EC-Numbers → 3 -- Hydrolases → 3.7 -- Acting on carbon-carbon bonds → 3.7.1 -- In ketonic substances

Synonyms: 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase, 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase (decyclizing)

Systematic Name: 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase (ring-opening)

Unification Links: BRENDA:3.7.1.21, ENZYME:3.7.1.21, IUBMB-ExplorEnz:3.7.1.21

Reaction:
6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H₂O ↔ 3-hydroxypimeloyl-CoA + H⁺

Enzymes and Genes:
6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase: bamA ( Syntrophus aciditrophicus )
6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase: oah ( Thauera aromatica )
6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase: Gmet_3305 ( Geobacter metallireducens )

Summary:
The enzyme, which participates in the anaerobic benzoyl-CoA degradation pathway in certain organisms, catalyses the addition of one molecule of water to the double bound of 6-oxocyclohex-1-ene-1-carbonyl-CoA followed by the hydrolytic C-C cleavage of the alicyclic ring.

Citations: [Laempe99, Kuntze08]

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References

Kuntze08: Kuntze K, Shinoda Y, Moutakki H, McInerney MJ, Vogt C, Richnow HH, Boll M (2008). "6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes." Environ Microbiol 10(6);1547-56. PMID: 18312395

Laempe99: Laempe D, Jahn M, Fuchs G (1999). "6-Hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase and 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase, enzymes of the benzoyl-CoA pathway of anaerobic aromatic metabolism in the denitrifying bacterium Thauera aromatica." Eur J Biochem 1999;263(2);420-9. PMID: 10406950

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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