[HTML][HTML] Glial cells: role of the immune response in ischemic stroke
S Xu, J Lu, A Shao, JH Zhang, J Zhang - Frontiers in immunology, 2020 - frontiersin.org
Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …
[HTML][HTML] Crosstalk of astrocytes and other cells during ischemic stroke
Stroke is a leading cause of death and long-term disability worldwide. Astrocytes structurally
compose tripartite synapses, blood–brain barrier, and the neurovascular unit and perform …
compose tripartite synapses, blood–brain barrier, and the neurovascular unit and perform …
[HTML][HTML] The role of SDF-1/CXCR4/CXCR7 in neuronal regeneration after cerebral ischemia
X Cheng, H Wang, X Zhang, S Zhao, Z Zhou… - Frontiers in …, 2017 - frontiersin.org
Stromal cell-derived factor-1 is a chemoattractant produced by bone marrow stromal cell
lines. It is recognized as a critical factor in the immune and central nervous systems (CNSs) …
lines. It is recognized as a critical factor in the immune and central nervous systems (CNSs) …
[HTML][HTML] M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice
Y Li, Z Liu, Y Song, J Pan, Y Jiang, X Shi, C Liu… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: White matter repair is critical for the cognitive and neurological functional
recovery after ischemic stroke. M2 microglia are well-documented to enhance remyelination …
recovery after ischemic stroke. M2 microglia are well-documented to enhance remyelination …
[HTML][HTML] Emerging roles of the atypical chemokine receptor 3 (ACKR3) in cardiovascular diseases
V Duval, P Alayrac, JS Silvestre… - Frontiers in Endocrinology, 2022 - frontiersin.org
Chemokines, and their receptors play a crucial role in the pathophysiology of cardiovascular
diseases (CVD). Chemokines classically mediate their effects by binding to G-protein …
diseases (CVD). Chemokines classically mediate their effects by binding to G-protein …
[HTML][HTML] cxcl12-engineered endothelial progenitor cells enhance neurogenesis and angiogenesis after ischemic brain injury in mice
Background Ischemic stroke causes a multitude of brain damage. Neurovascular injury and
myelin sheath degradation are two manifestations of ischemic brain damage. Therapeutic …
myelin sheath degradation are two manifestations of ischemic brain damage. Therapeutic …
[HTML][HTML] Hypoxia response element-regulated MMP-9 promotes neurological recovery via glial scar degradation and angiogenesis in delayed stroke
Matrix metalloproteinase 9 (MMP-9) plays a beneficial role in the delayed phase of middle
cerebral artery occlusion (MCAO). However, the mechanism is obscure. Here, we …
cerebral artery occlusion (MCAO). However, the mechanism is obscure. Here, we …
[HTML][HTML] Oligodendrocyte precursor cells transplantation improves stroke recovery via oligodendrogenesis, neurite growth and synaptogenesis
Ischemic-induced white matter injury is strongly correlated with the poor neurological
outcomes in stroke patients. The transplantation of oligodendrocyte precursor cells (OPCs) …
outcomes in stroke patients. The transplantation of oligodendrocyte precursor cells (OPCs) …
ACT‐1004‐1239, a first‐in‐class CXCR7 antagonist with both immunomodulatory and promyelinating effects for the treatment of inflammatory demyelinating diseases
L Pouzol, N Baumlin, A Sassi, M Tunis… - The FASEB …, 2021 - Wiley Online Library
Current strategies for the treatment of demyelinating diseases such as multiple sclerosis
(MS) are based on anti‐inflammatory or immunomodulatory drugs. Those drugs have the …
(MS) are based on anti‐inflammatory or immunomodulatory drugs. Those drugs have the …
Chemokines play complex roles in cerebral ischemia
C Chen, SF Chu, DD Liu, Z Zhang, LL Kong… - Neurochemistry …, 2018 - Elsevier
Ischemic stroke (IS) is a disease caused by deficiency of blood and oxygen in focal or
complete brain, followed by inflammation cascade and other pathological reactions, which …
complete brain, followed by inflammation cascade and other pathological reactions, which …