Volume 34, No 6, Jun 2024

ISSN: 1001-0602 
EISSN: 1748-7838  
2020 impact factor 25.617*  
(Clarivate Analytics, 2021)

About the cover

A Nian beast (proinflammatory PD-1+ T cells) wreaks havoc in the village (a metaphor for atherosclerosis, AS) on New Year's Eve. A man, dressed in red, ignites firecrackers (FcgR-binding anti-PD-1 mAb), preventing the Nian beast from causing trouble in the village (the shrinkage of AS plaques). See page 407–427 by Lin Fan et al. for details.

Advanced Online Publication: 25 Jun 2024

ORIGINAL ARTICLES

Localized, highly efficient secretion of signaling proteins by migrasomes

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Current Issue: Vol.34 (Jun 2024)

RESEARCH HIGHLIGHTS

Peripheral cancer remodeling of central neural system
ATP6AP1 was Phast-ID’ed as a long-sought GEF for Rheb
Decoding T cell state-specific regulomes in cancer
A tale of two calcium channels: structural pharmacology of Cav2.1 and Cav3.2
Cytolytic too: Granzyme B-expressing human ILC2s mediate tumor rejection
The hidden face of GluD1 at inhibitory synapses

ORIGINAL ARTICLES

Targeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans
Structural insights into human exon-defined spliceosome prior to activation
Structural basis for human Cav3.2 inhibition by selective antagonists

LETTERS TO THE EDITOR

APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APP^NL-G-F cerebral organoid model of Alzheimer’s disease
Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Ca_v2.1 channels
Substrate and drug recognition mechanisms of SLC19A3

CORRIGENDA

Author Correction: Substrate and drug recognition mechanisms of SLC19A3