Abstract
Repulsive guidance molecules (RGMs) are a group of glycosylphosphatidylinositol (GPI)-linked cellmembrane- associated proteins recently described. RGM family members play a diverse role in axonal guidance during embryo development, neuronal cell adhesion and regulation of systemic iron metabolism. Another important role of the RGM family, discovered recently, is that they act as co-receptors of bone morphogenetic proteins (BMPs), a group of proteins that are involved in bone development and the differentiation and progression of cancer. This indicates the potential impact of RGMs on cancer. The current review discusses the present knowledge on RGMs, their roles in BMP signalling and their potential implication in development and progression of cancer, particularly in the BMPs related bone metastasis.
Keywords: Repulsive guidance molecules (RGM), Neogenin, BMP signalling pathway, Smad, Cancer
Current Signal Transduction Therapy
Title:Repulsive Guidance Molecules (RGMs) and Their Potential Implication in Cancer as Co-receptor of BMPs
Volume: 7 Issue: 2
Author(s): Jin Li, Lin Ye and Wen G. Jiang
Affiliation:
Keywords: Repulsive guidance molecules (RGM), Neogenin, BMP signalling pathway, Smad, Cancer
Abstract: Repulsive guidance molecules (RGMs) are a group of glycosylphosphatidylinositol (GPI)-linked cellmembrane- associated proteins recently described. RGM family members play a diverse role in axonal guidance during embryo development, neuronal cell adhesion and regulation of systemic iron metabolism. Another important role of the RGM family, discovered recently, is that they act as co-receptors of bone morphogenetic proteins (BMPs), a group of proteins that are involved in bone development and the differentiation and progression of cancer. This indicates the potential impact of RGMs on cancer. The current review discusses the present knowledge on RGMs, their roles in BMP signalling and their potential implication in development and progression of cancer, particularly in the BMPs related bone metastasis.
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Cite this article as:
Li Jin, Ye Lin and G. Jiang Wen, Repulsive Guidance Molecules (RGMs) and Their Potential Implication in Cancer as Co-receptor of BMPs, Current Signal Transduction Therapy 2012; 7 (2) . https://dx.doi.org/10.2174/157436212800376690
DOI https://dx.doi.org/10.2174/157436212800376690 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
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