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J Exp Med. 1989 May 1; 169(5): 1835–1840.
doi: 10.1084/jem.169.5.1835
PMCID: PMC2189314
PMID: 2654325

Plasmodium falciparum-infected erythrocytes form spontaneous erythrocyte rosettes

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Abstract

Erythrocytes infected with trophozoites or schizonts of Plasmodium falciparum bind uninfected erythrocytes, leading to rosette formation. Both established laboratory strains and fresh isolates from patients form such rosettes, but at widely different frequencies. IgG preparations from the serum of some P. falciparum-immune donors and heparin inhibited rosette formation. The results indicate that cytoadherence of infected erythrocytes to endothelial cells and rosetting represent distinct genetic traits.

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Selected References

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