Learn more: PMC Disclaimer | PMC Copyright Notice
Original research
Long-term trends and regional variations of hypertension incidence in China: a prospective cohort study from the China Health and Nutrition Survey, 1991–2015
4Abstract
Objective
The aim is to explore the trends of hypertension incidence and regional variations in China from 1991 to 2015.
Design
A dynamic prospective cohort study.
Setting
China Health and Nutrition Survey 1991–2015.
Participants
12 952 Chinese adults aged 18+ years.
Primary outcome measures
Incident hypertension from 1993 to 2015.
Results
Age-standardised hypertension incidence increased from 40.8 per 1000 person-years (95% CI 38.3 to 43.4) between 1993 and 1997 to 48.6 (95% CI 46.1 to 51.0) between 2011 and 2015. The increasing trends were further supported by results from subsequent extended Cox proportional hazard model. In addition, results from the modelling analysis showed that individuals in eastern, central and northeastern China had greater risks of hypertension occurrence in comparison with their counterparts in western China.
Conclusion
Hypertension incidence increased during the study period. The growth called for more attention on the health education and health promotion of individuals with great risks.
Introduction
Along with ageing population, non-communicable chronic diseases, particularly stroke and ischaemic heart disease, have led to great burden of disease, deaths and years of life lost in both developed and developing countries.1 2 Connected closely with various cardiovascular diseases,3 4 high systolic blood pressure (SBP) was ranked as the leading risk factor of risk-attributable disability-adjusted life-years (DALYs) among selected 195 countries and territories.5 For instance, high SBP accounted for 2.54 million deaths and more than 5% of DALYs in China in 2017.6
Existing evidence has confirmed a worldwide high prevalence of hypertension.4–6 Countries, such as Singapore6 and Korea,7 had a significant proportion of individuals with hypertension. Likewise, with the extended life expectancy,8 changes in lifestyle behaviours,9 and rapid urbanisation,10 developing countries, such as China, experienced a substantial increase in the prevalence of hypertension, ranging from 13.6% in 1991 to 27.9% in 2015.11
Although the increasing prevalence of hypertension provided critical information for public health practice and disease control programmes, it could not accurately depict the epidaemiological transition as the incidence measure.12 Prior studies have indicated that the increasing prevalence could coexist with the decreasing incidence in the context of healthy ageing.13 For evidence-based health-promoting initiatives, empirical research on hypertension incidence is warranted.
However, research on the long-term trends of the incidence of hypertension from China is scare and relatively outdated.14 15 This is an important knowledge gap because developing countries are experiencing unprecedented social development. Up-to-date information among developing countries could greatly contribute to depict global epidaemiological transitions. Moreover, regional disparities are a major health concern in China as a result of inequitable socioeconomic development and healthcare resource distribution,16–18 while the existing research provides insufficient information regarding the regional disparities in the hypertension incidence.19–21
Hence, this study aims to explore the long-term trends of hypertension incidence among Chinese from diverse social and geographic contexts. In addition, we are particularly interested in regional variations while taking the individual-level risk factors into account.
Methods
Data source
The present study derived data from the China Health and Nutrition Survey (CHNS). CHNS has been collaboratively conducted by Carolina Population Center at the University of North Carolina at Chapel Hill and the National Institute for Nutrition and Health (former National Institute of Nutrition and Food Safety) at the Chinese Center for Disease Control and Prevention. Initiated in 1989, CHNS consisted of 10-wave data in 1989, 1991, 1993, 1997, 2000, 2004, 2006, 2009, 2011 and 2015, respectively. Overall, CHNS employed a multistage random cluster method to draw the study sample, which included over 30 000 individuals from three provincial-level cities and 12 provinces. Individuals in the survey came from diverse social, geographic and cultural contexts. CHNS employed face-to-face questionnaire interviews to collect data, and the physical health examinations were conducted by well-trained investigators. Information regarding survey design, data collection, and quality control could be retrieved from the cohort profile.22
Study design and exclusion criteria
The present study employed a dynamic cohort study design as not all individuals entered the cohort at the same time. To evaluate the long-term trends of hypertension incidence, we excluded individuals (a) without individual ID and community ID; (b) aged under 18 years because of the low incidence of hypertension among children and teenagers; (c) with hypertension in his/her first investigation; (d) with only one observation or only one record of hypertension status and (e) who were pregnant during the study period to exclude gestational hypertension. Furthermore, we excluded observations after the diagnosis of hypertension (figure 1). As death data were not available in CHNS, censoring could be for death or lost to follow-up.
Exposures
The primary exposure variable of this study were the timing of entering the cohort and geographic regions. For modelling analyses, it was not feasible to treat the waves as continuous variables, and therefore, we respectively grouped the individuals entering the cohort from (a) 1991, 1993 and 1997; (b) 2000, 2004, 2006 and 2009 and (c) 2011 and 2015. In this case, two dummies were introduced in the model with individuals from 1991 to 1997 as the reference group.
Geographic regions were defined according to the bulletin of the National Bureau of Statistics of China. Specifically, we grouped individuals from (a) Beijing, Shanghai, Jiangsu Province, Zhejiang Province and Shandong Province as eastern China; (b) Henan Province, Hubei Province and Hunan Province as central China; (c) Liaoning Province and Heilongjiang Province as northeastern China and (d) Yunnan Province, Guangxi Zhuang Autonomous Region, Guizhou Province, Chongqing and Shanxi Province as western China.
Outcomes
We included incidence of hypertension as the primary outcome. First, we adopted self-reported hypertension, which was derived from the answer to the question, ‘Has a doctor ever told you that you had high blood pressure?’. If individuals self-reported no hypertension history, the outcomes would be further supplemented by the blood pressure tests to avoid the recall bias and underestimation from self-reported measures. According to the criteria of the 2018 Clinical Guideline in China and the 2018 ESC/ESH HTN Guideline,23 hypertension was confirmed with the SBP ≥140 mm Hg or with the diastolic blood pressure ≥90 mm Hg. To guarantee the accuracy of the tests, the blood pressure was detected in triplicate by professional health workers on the same day.
Covariates
To adjust for variations in baseline characteristics, we introduced several confounding factors that may influence the occurrence of hypertension. These factors included urban versus rural settings, sociodemographic characteristics (age, sex, race, marital status, educational attainment and employment status) and lifestyle attributes (body mass index (BMI), smoking behaviours, alcohol consumption and physical activity).15 24
Statistical analysis
First, we performed χ2 tests and Kruskal-Wallis rank-sum tests to evaluate variations in baseline characteristics over time. Second, we calculated the crude incidence of hypertension as below25:
The ‘person-years at risk’ is the period from the first hypertension-free year to the year when the subsequent hypertension is confirmed. In addition, we conducted direct standardisation to calculate the age-standardised incidence of hypertension by using the study sample from wave 2011 to wave 2015 as the standard population. Subgroup analyses were conducted by sex.
To further evaluate the long-term trends and geographic variations of incident hypertension, we performed an extended Cox proportional hazard model while including all covariates to control for baseline variations. Because the effect of age did not conform to the proportional hazard assumption, we performed a time-dependent Cox regression model with age as a time-dependent variable. As for sensitivity analyses, we construct the multi-level Poisson regression indicating similar findings.
Data analyses were performed with Stata V.15.0 (StataCorp, Texas, USA). A two-tailed p value of less than 0.05 was considered statistical significance.
Patient and public involvement
Patients and the public were not involved in the research.
Results
Study population
The CHNS consisted of data of 38 558 individuals with 143 586 observations from 1989 to 2015, and the present study only included 12 952 individuals from 1991 to 2015 after sample selection (figure 1). Table 1 presents the distribution of observations from included individuals during the study period. For example, 5938 individuals entered the cohort in 1991, with only 912 followed-up in 2015 (table 1). Among the 12 952 participants, 5119 of them developed hypertension during the follow-up period.
Table 1
Observation distribution of study sample from 1991 to 2015
| Wave | 1991 | 1993 | 1997 | 2000 | 2004 | 2006 | 2009 | 2011 | 2015 |
| 1989 | |||||||||
| 1991 | 5938 | ||||||||
| 1993 | 5166 | 677 | |||||||
| 1997 | 3313 | 485 | 1691 | ||||||
| 2000 | 2658 | 335 | 1451 | 1009 | |||||
| 2004 | 2050 | 234 | 1037 | 813 | 837 | ||||
| 2006 | 1722 | 188 | 865 | 642 | 684 | 376 | |||
| 2009 | 1378 | 142 | 385 | 398 | 413 | 302 | 692 | ||
| 2011 | 1200 | 114 | 329 | 335 | 359 | 216 | 630 | 1732 | |
| 2015 | 912 | 86 | 250 | 236 | 231 | 152 | 353 | 1732 | 0 |
Table 2 presents the baseline characteristics of the study sample. Overall, variations existed in all baseline characteristics. Newly recruited individuals were older (p<0.001) and well educated (p<0.001). They were more likely to be obese (p<0.001), Han (p<0.001) and men (p<0.001), and they were less likely to be smokers (p<0.001), employed (p<0.001) and physically active (p<0.001).
Table 2
Baseline characteristics of study individuals, n (%)*
| Characteristic | Time entering the cohort | P value | ||
| 1991–1997 | 2000–2009 | 2011–2015 | ||
| Region | ||||
| Western | 2256 (27.16) | 611 (20.97) | 523 (30.20) | <0.001 |
| Central | 2817 (33.92) | 800 (27.45) | 85 (4.91) | |
| Northeastern | 1288 (15.51) | 794 (27.25) | 83 (4.79) | |
| Eastern | 1945 (23.42) | 709 (24.33) | 1041 (60.10) | |
| Urban–rural | ||||
| Rural | 5616 (67.61) | 1717 (58.92) | 777 (44.86) | <0.001 |
| Urban | 2690 (32.39) | 1197 (41.08) | 955 (55.14) | |
| Age (years) | ||||
| 18–29 | 2374 (28.58) | 695 (23.85) | 221 (12.76) | <0.001 |
| 30–39 | 2382 (28.68) | 854 (29.31) | 345 (19.92) | |
| 40–49 | 1752 (21.09) | 621 (21.31) | 424 (24.48) | |
| 50–59 | 1004 (12.09) | 405 (13.90) | 456 (26.33) | |
| ≥60 | 794 (9.56) | 339 (11.63) | 286 (16.51) | |
| Sex | ||||
| Male | 3986 (47.99) | 1168 (40.08) | 736 (42.49) | <0.001 |
| Female | 4320 (52.01) | 1746 (59.92) | 996 (57.51) | |
| BMI (kg/m2) | ||||
| <18.5 | 763 (9.27) | 191 (6.60) | 60 (3.46) | <0.001 |
| 18.5–23.9 | 6012 (73.07) | 1776 (61.35) | 955 (55.14) | |
| 24.0–27.9 | 1238 (15.05) | 760 (26.25) | 545 (31.47) | |
| ≥28 | 215 (2.61) | 168 (5.80) | 172 (9.93) | |
| Race | ||||
| Other | 1038 (12.59) | 340 (11.69) | 72 (4.17) | <0.001 |
| Han | 7204 (87.41) | 2568 (88.31) | 1656 (95.83) | |
| Marital status | ||||
| Other | 1183 (14.29) | 341 (11.82) | 192 (11.14) | <0.001 |
| Married | 7098 (85.71) | 2545 (88.18) | 1531 (88.86) | |
| Education attainment | ||||
| Primary school and below | 4416 (53.81) | 741 (26.43) | 410 (23.73) | <0.001 |
| Middle school | 2377 (28.97) | 1103 (39.34) | 457 (26.45) | |
| High school or equivalent | 1240 (15.11) | 742 (26.46) | 472 (27.31) | |
| College and above | 173 (2.11) | 218 (7.77) | 389 (22.51) | |
| Employed | ||||
| No | 1145 (13.85) | 1044 (35.95) | 716 (41.34) | <0.001 |
| Yes | 7121 (86.15) | 1860 (64.05) | 1016 (58.66) | |
| Smoking history | ||||
| Never or smoking cessation | 5300 (64.72) | 2163 (74.97) | 1326 (77.18) | <0.001 |
| Current smoker, cigarettes ＜20/day | 1481 (18.09) | 370 (12.82) | 205 (11.93) | |
| Current smoker, cigarettes ≥20/day | 1408 (17.19) | 352 (12.20) | 187 (10.88) | |
| Alcohol consumption | ||||
| Never | 5042 (61.82) | 2037 (70.93) | 1116 (65.03) | <0.001 |
| Not more than once per month | 469 (5.75) | 102 (3.55) | 144 (8.39) | |
| 1–3 times per month | 661 (8.10) | 173 (6.02) | 127 (7.40) | |
| 1–2 times per week | 781 (9.58) | 227 (7.90) | 127 (7.40) | |
| 3–4 times per week | 450 (5.52) | 126 (4.39) | 64 (3.73) | |
| On a daily basis | 753 (9.23) | 207 (7.21) | 138 (8.04) | |
| Physical activity | ||||
| Very light | 997 (12.56) | 780 (27.73) | 823 (49.46) | <0.001 |
| Light | 1307 (16.46) | 799 (28.40) | 453 (27.22) | |
| Moderate | 1291 (16.26) | 461 (16.39) | 209 (12.56) | |
| Heavy or very heavy | 4344 (54.71) | 773 (27.48) | 179 (10.76) | |
*Overall, we included 11 685 individuals in the modelling analyses after excluding 97 individuals without body mass index, 74 without race, 62 without marital status, 214 without educational attainment, 50 without employment status, 160 without smoking history, 208 without alcohol consumption and 449 without physical activity. (Missing rate 9.78%.)
Crude and age-standardised incidence
Table 3 presents the crude and age-standardised hypertension incidence during the study period. For the calculation of hypertension incidence, we employed the full sample of 12 952 individuals with 53 703 observations. The age-standardised incidence of hypertension witnessed a significant increase, ranging from 40.8 per 1000 person-years (95% CI 38.3 to 43.4) between 1993 and 1997 to 48.6 per 1000 person-years (95% CI 46.1 to 51.0) between 2011 and 2015. The increasing pattern was also exhibited among men (1993–1997: 46.2, 95% CI 42.1 to 50.4; 2011–2015: 55.7, 95% CI 51.7 to 59.7) and women (1993–1997: 36.5, 95% CI 33.2 to 39.7; 2011–2015: 43.3, 95% CI 40.2 to 46.3).
Table 3
Crude and age-standardised incidence over time per 1000 person-years
| Incidence | 1991 | 1993–1997 | 2000–2009 | 2011–2015 |
| Total | ||||
| Case (person-year) | – | 1114 (35 486) | 2571 (70 575) | 1434 (29 492) |
| Crude incidence (95% CI) | – | 31.3 (29.6 to 33.2) | 36.4 (35.0 to 37.8) | 48.6 (46.1 to 51.2) |
| Age-standardised incidence (95% CI)* | – | 40.8 (38.3 to 43.4) | 41.5 (39.9 to 43.2) | 48.6 (46.1 to 51.0) |
| Male | ||||
| Case (person-year) | – | 594 (17 530) | 1292 (32 524) | 699 (12 532) |
| Crude incidence (95% CI) | – | 33.8 (31.2 to 36.7) | 39.7 (37.6 to 41.9) | 55.7 (51.7 to 60.0) |
| Age-standardised incidence (95% CI)* | – | 46.2 (42.1 to 50.4) | 45.7 (43.0 to 48.3) | 55.7 (51.7 to 59.7) |
| Female | ||||
| Case (person-year) | – | 520 (17 956) | 1279 (38 051) | 735 (16 960) |
| Crude incidence (95% CI) | – | 28.9 (26.5 to 31.5) | 33.6 (31.8 to 35.5) | 43.3 (40.3 to 46.5) |
| Age-standardised incidence (95% CI)* | – | 36.5 (33.2 to 39.7) | 38.0 (35.9 to 40.1) | 43.3 (40.2 to 46.3) |
*Age-standardised incidence was calculated using the study sample in 2011–2015 as the standard population.
Extended COX proportional hazard analysis
For the modelling analysis, we included 11 685 individuals without missing data (missing rate, 9.78%). Among the identified cases, the duration from free of hypertension to incident hypertension ranged from 2 to 24 years, with a median of 9 years.
Table 4 presents results from extended Cox proportional hazard analysis while taking variations in baseline characteristics into account. First, the increasing trends of hypertension incidence were robust, as suggested by the modelling results. Specifically, individuals entering the cohort from 2000 to 2009 (ajusted Hazard Ratio (aHR)=1.10, 95% CI 1.01 to 1.21) and those from 2011 to 2015 (aHR=1.19, 95% CI 1.04 to 1.37) had a higher risk of hypertension in comparison with individuals entering the cohort from 1991 to 1997. With reference to regional variations, individuals in central (aHR=1.26, 95% CI 1.16 to 1.37), northeastern (aHR=1.56, 95% CI 1.41 to 1.72) and eastern China (aHR=1.48, 95% CI 1.36 to 1.63), respectively, had a higher risk of hypertension occurrence relative to their counterparts in western China.
Table 4
Extended Cox proportional hazard analysis of hypertension incidence
| Characteristic | aHR (95% CI) | P value |
| Timing of entering the cohort | ||
| 1991–1997 | Ref. | |
| 2000–2009 | 1.10 (1.01 to 1.21) | 0.025 |
| 2011–2015 | 1.19 (1.04 to 1.37) | 0.010 |
| Geographic region | ||
| Western | Ref. | |
| Central | 1.26 (1.16 to 1.37) | <0.001 |
| Northeastern | 1.56 (1.41 to 1.72) | <0.001 |
| Eastern | 1.48 (1.36 to 1.63) | <0.001 |
| Urban (vs rural) | 0.94 (0.88 to 1.01) | 0.109 |
| Age* | ||
| 18–29 | Ref. | |
| 30–39 | 1.93 (1.41 to 2.65) | <0.001 |
| 40–49 | 3.99 (2.93 to 5.43) | <0.001 |
| 50–59 | 5.16 (3.74 to 7.12) | <0.001 |
| ≥60 | 9.11 (6.50 to 12.77) | <0.001 |
| Female (vs male) | 0.81 (0.74 to 0.88) | <0.001 |
| Body mass index (kg/m2) | ||
| <18.5 | Ref. | |
| 18.5–23.9 | 1.31 (1.16 to 1.48) | <0.001 |
| 24.0–27.9 | 2.07 (1.81 to 2.36) | <0.001 |
| ≥28 | 2.82 (2.37 to 3.34) | <0.001 |
| Race (Han vs others) | 1.11 (1.01 to 1.23) | 0.032 |
| Married (vs others) | 0.92 (0.83 to 1.02) | 0.149 |
| Educational attainment | ||
| Primary school and below | Ref. | |
| Middle school | 0.91 (0.84 to 0.99) | 0.020 |
| High school or equivalent | 0.86 (0.77 to 0.95) | 0.002 |
| College and above | 0.82 (0.68 to 0.98) | 0.033 |
| Employed (yes vs no) | 0.90 (0.82 to 0.99) | 0.036 |
| Smoking | ||
| Never or smoking cessation | Ref. | |
| Current smoker, cigarettes <20/day | 0.98 (0.89 to 1.07) | 0.752 |
| Current smoker, cigarettes ≥20/day | 1.05 (0.96 to 1.16) | 0.237 |
| Alcohol consumption | ||
| Never | Ref. | |
| Not more than once per month | 0.89 (0.78 to 1.03) | 0.125 |
| 1–3 times per month | 1.17 (1.04 to 1.32) | 0.006 |
| 1–2 times per week | 1.00 (0.89 to 1.12) | 0.963 |
| 3–4 times per week | 1.05 (0.92 to 1.21) | 0.412 |
| On a daily basis | 1.18 (1.06 to 1.31) | 0.002 |
| Physical activity | ||
| Very light | Ref. | |
| Light | 0.92 (0.83 to 1.02) | 0.154 |
| Moderate | 0.99 (0.88 to 1.11) | 0.930 |
| Heavy and very heavy | 0.91 (0.82 to 1.02) | 0.118 |
*Estimated time effect of age, p<0.001.
In addition, there existed no urban–rural differences in developing hypertension (table 4). Risks of incident hypertension increased with age, BMI and alcohol consumption, while it was negatively associated with educational attainment. Women had a lower risk of incident hypertension compared with men (aHR=0.81, 95% CI 0.74 to 0.88). Relative to those without a job, employees had a lower risk of developing hypertension (aHR=0.90, 95% CI 0.82 to 0.99). Han individuals were significantly associated with a higher risk (aHR=1.11, 95% CI 1.01 to 1.23) relative to the minority.
Discussion
By employing a study sample of 12 925 individuals from diverse social and geographic contexts, we found the age-standardised incidence of hypertension increased during the study period. The increasing pattern remained even after controlling for variations in baseline characteristics. Furthermore, we found that individuals in economically developed eastern, central and northeastern China had greater risks of incident hypertension in comparison with those in western China.
Instead of focusing on the incidence measure, the vast majority of prior studies focused on the prevalence measure. For example, one of the previous studies in China indicated that the prevalence of hypertension rose substantially from 13.6% in 1991 to 27.9% in 2015.11 The findings were further supplemented by results from Lu et al, which suggested a higher prevalence of hypertension among those aged between 35 and 75 years (44.7%).26 Compared with these earlier studies, our focus on the incidence measure provided a more accurate reflection of the epidaemiologic transition of hypertension in China.12 Our findings updated the trends of hypertension incidence in comparison with that from Liang et al, which indicated a similar pattern from 1991 to 2009.15 Even though hypertension incidence appeared to vary across countries,27–29 the comparison is untenable because we adopted different standard populations. Further empirical research across countries is warranted.
With the rapid economic development, people often change their dietary patterns from light diet to high salt and fat diet along with a secondary lifestyle.30 These changes would significantly impact the prevalence and control of hypertension in China.30 In addition, due to data limitation, we were unable to introduce several potential risks factors, such as sodium intake or dietary pattern, parental history, psychological status, ambient air pollutants, working hours and household income.31–34 These factors may explain the residual time effects in the model.
Although existing evidence on the regional disparities of hypertension incidence is scant, prior research indicates that central, northeastern and eastern China had a higher prevalence of hypertension compared with western China,35 which is in line with our findings. In sharp contrast, prior investigators have noted that northeastern and central China had lower all-cause mortality rates relative to western China.36 These findings appear to suggest that individuals in China’s economically developed regions are experiencing extended life expectancy with relatively unhealthy ageing.12 However, one should be aware of the possibility that although individuals in western China had lower risks of hypertension compared with the other three regions, local public awareness and timely treatment could be a challenging issue.
Differed from previous studies,15 37 no urban–rural disparities were observed in the present study. This may be a result of the narrowing gap of lifestyle between rural and urban residents. With the rapid economic development and urbanisation in the past few decades, the lifestyle and dietary pattern of rural residents are approaching to those of their counterparts in urban China.9 10 This possibility has been further supported by the fact that the prevalence of hypertension in rural China exceeded that of urban China in 2015.26 Taking into account the lower treatment rate and insufficient awareness among rural residents,38 one should direct more attention to rural China.
Moreover, we found that smoking history was not associated with incident hypertension. The effect of smoking on the development of the chronic disease is unclear and appears to differ across life courses.39–41 Prior research based on Korean has found a J-shaped association between physical activity and incident hypertension,42 while the present study on Chinese did not observe a similar association, which is in line with findings based on Japanese.43 The effect of physical activity on the development of hypertension seems to be controversial and varies across countries. Further analyses are warranted.
Consistent with the previous studies,44–47 several risk factors, including age, gender, educational attainment, race, alcohol consumption and BMI, were confirmed by our analyses. The growing incidence of hypertension emphasises the early prevention, education, detection and management for hypertension.48 Mentoring aforementioned lifestyle behaviours, such as alcohol consumption, may be helpful to constrain the hypertension incidence.49 Public health and lifestyle interventions targeting high-risk individuals, such as older adults, men and obese population, hold promise.
Conclusion
Hypertension incidence increased during the study period. Individuals in eastern, central and northeastern China had greater risks of hypertension in comparison with their counterparts in western China. Risks of incident hypertension increased with age, BMI and alcohol consumption but negatively associated with educational attainment. The growth of hypertension incidence calls for more attention on the health education and health promotion of individuals with great risks.
Strengths and limitations of this study
The present study has two major strengths. First, the dynamic cohort study design employed individuals from diverse social and geographic contexts, which enabled us to depict the long-term trends of hypertension incidence and regional disparities in the context of China’s rapid social development and population ageing. In addition, we adopted both self-reported health outcomes and objective outcomes from physical tests, which avoided the recall bias and underestimation in underserved areas.
Nevertheless, this study is subject to several limitations. First, we did not employ a national representative sample and did not include individuals from all provinces in China, which undermined the representation of our findings. As a community-based survey, the CHNS excluded institutionalised individuals, which further diminished the representation of our findings among Chinese. Third, 2018 Clinical Guideline in China recommend to identify hypertension cases by using blood pressure values that are measured in different days,23 while individuals’ blood pressure data in the CHNS were collected on the same day in the CHNS, leading to unavoidable bias. Last, we did not distinguish the grade of hypertension, and future research is necessary.
Supplementary Material
Acknowledgments
We thank the National Institute for Nutrition and Health, China Center for Disease Control and Prevention, Carolina Population Center (P2C HD050924, T32 HD007168), the University of North Carolina at Chapel Hill, the NIH (R01-HD30880, DK056350, R24 HD050924 and R01-HD38700) and the NIH Fogarty International Center (D43 TW009077 and D43 TW007709) for financial support for the CHNS data collection and analysis files from 1989 to 2015 and future surveys, and the China-Japan Friendship Hospital, Ministry of Health for support for CHNS 2009, Chinese National Human Genome Center at Shanghai since 2009 and Beijing Municipal Center for Disease Prevention and Control since 2011.
Footnotes
Correction notice: This article has been corrected since it first published. The provenance and peer review statement has been included.
Contributors: WZ designed this study and revised the manuscript. YL, FX and XY performed data clean, statistical analysis and wrote the first draft of the manuscript, which PL and WH subsequently revised. All authors read the article and approve it for publication.
Funding: This study was supported by China’s National Development and Reform Commission Grant (No. 2018GFGW001) to WZ.
Competing interests: None declared.
Patient and public involvement: Patients and/or the public were not involved in the design, or conduct, or reporting or dissemination plans of this research.
Provenance and peer review: Not commissioned; externally peer reviewed.
Data availability statement
Data are available in a public, open access repository. Data are available from China Health and Nutrition Survey (https://www.cpc.unc.edu/projects/china/data/).
Ethics statements
Patient consent for publication
Not required.
Ethics approval
China Health and Nutrition Survey (CHNS) was approved by the ethics committee of Carolina Population Center at the University of North Carolina at Chapel Hill and the NINH at the CCDC. Informed consent was obtained from all subjects before the investigation.