The clearance of procalcitonin (PCT) during continuous veno-venous hemodiafiltration (CVVHD)
- PMID: 10551988
- DOI: 10.1007/s001340051041
The clearance of procalcitonin (PCT) during continuous veno-venous hemodiafiltration (CVVHD)
Abstract
Objective: To evaluate the Procalcitonin (PCT) clearance during continuous veno-venous hemodiafiltration (CVVHD).
Design: Case report
Setting: ++ Surgical intensive care unit.
Patient: 51-year-old man, who had undergone total thyroidectomy about ten years before owing to multiple endocrine neoplasia 2 (MEN 2), suffering from multiple organ dysfunction syndrome (MODS) with acute renal failure after severe trauma caused by a traffic accident.
Measurements and main result: The samplings of prefilter (afferent) and post-filter (efferent) blood and of ultradiafiltrate were 6 times performed during 24 h of CVVHD to calculate the PCT clearance of hemdiafiltration. During the first half period of CVVHD the serum PCT concentration did not decrease, though PCT had been eliminated from serum. On the other hand during the latter half period of it the serum PCT value decreased (from 46.8 ng/ml to 29.4 ng/ml) and the amount of the eliminated PCT from serum was about 100 ng per minute and its clearance was 2.3 approximately 3.4 ml/min.
Conclusion: The CVVHD could eliminate PCT from serum. First it was brought about by the adsorption by the filter membrane and then by ultradiafiltration.
Similar articles
-
The efficacy of procalcitonin as a biomarker in the management of sepsis: slaying dragons or tilting at windmills?Surg Infect (Larchmt). 2013 Dec;14(6):489-511. doi: 10.1089/sur.2012.028. Epub 2013 Nov 25. Surg Infect (Larchmt). 2013. PMID: 24274059 Review.
-
Influence of continuous veno-venous haemodiafiltration and continuous veno-venous haemofiltration on the pharmacokinetics of fluconazole.Eur J Clin Pharmacol. 2000 Dec;56(9-10):671-8. doi: 10.1007/s002280000216. Eur J Clin Pharmacol. 2000. PMID: 11214774 Clinical Trial.
-
Elimination of procalcitonin and plasma concentrations during continuous veno-venous haemodiafiltration in septic patients.Eur J Anaesthesiol. 2000 Nov;17(11):665-71. doi: 10.1046/j.1365-2346.2000.00758.x. Eur J Anaesthesiol. 2000. PMID: 11029564
-
Acute renal failure in the critically ill: management by continuous veno-venous hemodiafiltration.J Crit Care. 1993 Sep;8(3):140-4. doi: 10.1016/0883-9441(93)90019-h. J Crit Care. 1993. PMID: 8275158
-
Interleukin-6 and interleukin-8 extraction during continuous venovenous hemodiafiltration in septic acute renal failure.Ren Fail. 1995 Jul;17(4):457-66. doi: 10.3109/08860229509037609. Ren Fail. 1995. PMID: 7569116
Cited by
-
Removal of Procalcitonin and Selected Cytokines during Continuous Veno-Venous Hemodialysis Using High Cutoff Hemofilters in Patients with Sepsis and Acute Kidney Injury.Blood Purif. 2018;46(2):153-159. doi: 10.1159/000488929. Epub 2018 Apr 27. Blood Purif. 2018. PMID: 29705804 Free PMC article.
-
Coupled Plasma Filtration Adsorption (CPFA) plus Continuous Veno-Venous Haemofiltration (CVVH) versus CVVH alone as an adjunctive therapy in the treatment of sepsis.EXCLI J. 2013 Aug 12;12:681-92. eCollection 2013. EXCLI J. 2013. PMID: 26600735 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
