Review
doi: 10.1023/a:1007652414175.
The proinflammatory transcription factor NFkappaB: a potential target for novel therapeutical strategies
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- PMID: 10811528
- DOI: 10.1023/a:1007652414175
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Review
The proinflammatory transcription factor NFkappaB: a potential target for novel therapeutical strategies
Cell Biol Toxicol.
1999.
Abstract
NFkappaB is a ubiquitous transcription factor involved in the proinflammatory response to cytokines (such as IL-1 or TNF-alpha) and some particular stresses. The unraveling of the molecular mechanisms involved in its activation is quite recent, particularly in the case of IL-1-stimulated cells, but the identification of the molecules involved in this pathway opens new prospects in both pharmacological and toxicological research.
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