Diseases caused by silica: mechanisms of injury and disease development
- PMID: 11811922
- DOI: 10.1016/s1567-5769(01)00170-9
Diseases caused by silica: mechanisms of injury and disease development
Abstract
While silica particles are considered to be fibrogenic and carcinogenic agents, the mechanisms responsible are not well understood. This article summarizes literature on silica-induced accelerated silicosis, chronic silicosis, silico-tuberculosis, bronchogenic carcinoma, and immune-mediated diseases. This article also discusses the generation of reactive oxygen species (ROS) that occurs directly from the interaction of silica with aqueous medium and from silica-stimulated cells, the molecular mechanisms of silica-induced lung injuries with focus on silica-induced NF-kappaB activation, including its mechanisms, possible attenuation and relationship to silica-induced generation of cyclooxygenase II and TNF-alpha. Silica-induced AP-1 activation, protooncogene expression, and the role of ROS in these processes are also briefly discussed.
Similar articles
-
Reactive oxygen species and molecular mechanism of silica-induced lung injury.J Environ Pathol Toxicol Oncol. 2001;20 Suppl 1:85-93. J Environ Pathol Toxicol Oncol. 2001. PMID: 11570677 Review.
-
Diseases associated with exposure to silica and nonfibrous silicate minerals. Silicosis and Silicate Disease Committee.Arch Pathol Lab Med. 1988 Jul;112(7):673-720. Arch Pathol Lab Med. 1988. PMID: 2838005 Review.
-
The relationship among silica, silicosis, and lung carcinoma.Ariz Med. 1981 Aug;38(8):596-8. Ariz Med. 1981. PMID: 6268025 No abstract available.
-
Silica, silicosis and tuberculosis.Int J Tuberc Lung Dis. 2007 May;11(5):474-84. Int J Tuberc Lung Dis. 2007. PMID: 17439668 Review.
-
Silica, silicosis, and lung cancer.Br J Ind Med. 1989 May;46(5):289-91. doi: 10.1136/oem.46.5.289. Br J Ind Med. 1989. PMID: 2546576 Free PMC article. Review. No abstract available.
Cited by
-
Enterosorbents in complex therapy of food allergies: a focus on digestive disorders and systemic toxicity in children.Front Immunol. 2023 Oct 13;14:1210481. doi: 10.3389/fimmu.2023.1210481. eCollection 2023. Front Immunol. 2023. PMID: 37901242 Free PMC article. Review.
-
Interplay of Oxidative Stress, Inflammation, and Autophagy in RAW 264.7 Murine Macrophage Cell Line Challenged with Si/SiO2 Quantum Dots.Materials (Basel). 2023 Jul 19;16(14):5083. doi: 10.3390/ma16145083. Materials (Basel). 2023. PMID: 37512357 Free PMC article.
-
Anomalous Enrichment of As and Hg in Underground Coal Dust: A Case from Xishan Coalfield, Shanxi Province, North China.ACS Omega. 2023 Apr 5;8(15):13884-13898. doi: 10.1021/acsomega.3c00300. eCollection 2023 Apr 18. ACS Omega. 2023. PMID: 37091386 Free PMC article.
-
The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat.Saf Health Work. 2023 Mar;14(1):118-123. doi: 10.1016/j.shaw.2023.02.001. Epub 2023 Feb 10. Saf Health Work. 2023. PMID: 36941929 Free PMC article.
-
Development of nintedanib nanosuspension for inhaled treatment of experimental silicosis.Bioeng Transl Med. 2022 Sep 19;8(2):e10401. doi: 10.1002/btm2.10401. eCollection 2023 Mar. Bioeng Transl Med. 2022. PMID: 36925690 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
