Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication
- PMID: 12417278
- DOI: 10.1016/s0021-9150(02)00235-6
Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication
Abstract
In patients with intermittent claudication, exercise is associated with a marked increase in oxidative stress, likely responsible for systemic endothelial perturbation. In 31 claudicant patients, we assessed the effect of vitamin C administration on the acute changes induced by maximal and submaximal exercise in endothelium-dependent, flow-mediated dilation (FMD), and in plasma levels of thiobarbituric acid-reactive substances (TBARS) and soluble intercellular adhesion molecule-1 (sICAM-1). In 16 claudicants, maximal exercise reduced FMD (from 8.5+/-0.9 to 3.7+/-0.8%, P<0.01), and increased plasma levels of TBARS (from 1.93+/-0.06 to 2.22+/-0.1 nmol/ml, P<0.02) and of sICAM-1 (from 282+/-17 to 323+/-19 ng/ml, P<0.01). In eight of these patients, randomized to vitamin C, exercise-induced changes in FMD and biochemistry were abolished. This beneficial effect was not observed in the eight patients randomized to saline. In 15 patients, who walked until the onset of claudication pain (submaximal exercise), and in ten control subjects, who performed maximal exercise, no changes were observed with exercise. Thus, in claudicants, vitamin C prevents the acute, systemic impairment in endothelial function induced by maximal exercise. This finding provides a rationale for trials investigating antioxidant therapy and cardiovascular risk in patients with intermittent claudication.
Similar articles
-
Blood Flow during Handgrip Exercise in COPD: Effect of Vitamin C.Med Sci Sports Exerc. 2016 Feb;48(2):200-9. doi: 10.1249/MSS.0000000000000766. Med Sci Sports Exerc. 2016. PMID: 26339724
-
Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients.Am J Hypertens. 2007 Apr;20(4):392-7. doi: 10.1016/j.amjhyper.2006.09.021. Am J Hypertens. 2007. PMID: 17386345 Clinical Trial.
-
Prevention by NCX 4016, a nitric oxide-donating aspirin, but not by aspirin, of the acute endothelial dysfunction induced by exercise in patients with intermittent claudication.Thromb Haemost. 2007 Mar;97(3):444-50. Thromb Haemost. 2007. PMID: 17334512 Clinical Trial.
-
Effect of propionylcarnitine on changes in endothelial function and plasma levels of adhesion molecules induced by acute exercise in patients with intermittent claudication.Angiology. 2006 Mar-Apr;57(2):145-54. doi: 10.1177/000331970605700203. Angiology. 2006. PMID: 16518521 Clinical Trial.
-
Exercise increases soluble adhesion molecules ICAM-1 and VCAM-1 in patients with intermittent claudication.Clin Hemorheol Microcirc. 2001;24(3):193-9. Clin Hemorheol Microcirc. 2001. PMID: 11455059
Cited by
-
Oxidative damage in the gastrocnemius predicts long-term survival in patients with peripheral artery disease.NPJ Aging. 2024 Apr 5;10(1):21. doi: 10.1038/s41514-024-00147-3. NPJ Aging. 2024. PMID: 38580664 Free PMC article.
-
Aortic blood pressure and pulse wave indices responses to exercise in peripheral artery disease.Am J Physiol Regul Integr Comp Physiol. 2023 Oct 1;325(4):R327-R336. doi: 10.1152/ajpregu.00303.2022. Epub 2023 Jul 24. Am J Physiol Regul Integr Comp Physiol. 2023. PMID: 37486070
-
Physiological Responses to Maximal and Submaximal Walking in Patients with Symptomatic Peripheral Artery Disease.Arq Bras Cardiol. 2021 Aug;117(2):309-316. doi: 10.36660/abc.20200156. Arq Bras Cardiol. 2021. PMID: 34495225 Free PMC article. English, Portuguese.
-
Regular, Intense Exercise Training as a Healthy Aging Lifestyle Strategy: Preventing DNA Damage, Telomere Shortening and Adverse DNA Methylation Changes Over a Lifetime.Front Genet. 2021 Aug 6;12:652497. doi: 10.3389/fgene.2021.652497. eCollection 2021. Front Genet. 2021. PMID: 34421981 Free PMC article. Review.
-
Phytochemicals as Therapeutic Interventions in Peripheral Artery Disease.Nutrients. 2021 Jun 22;13(7):2143. doi: 10.3390/nu13072143. Nutrients. 2021. PMID: 34206667 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical