Effect of action potential duration and conduction velocity restitution and their spatial dispersion on alternans and the stability of arrhythmias
- PMID: 12475106
- DOI: 10.1046/j.1540-8167.2002.01141.x
Effect of action potential duration and conduction velocity restitution and their spatial dispersion on alternans and the stability of arrhythmias
Abstract
Introduction: The slope of the action potential duration (APD) restitution curve has been used to explain wavebreaks during arrhythmia initiation and maintenance. This hypothesis remains incomplete to fully describe the experimental data. Other factors contributing to wavebreaks must be studied to further understand arrhythmia dynamics.
Methods and results: Control APDs were measured from isolated rabbit hearts using a monophasic action potential probe. APD and conduction velocity (CV) restitution were quantified over the heart surface for two drugs, diacetyl monoxime (DAM) and cytochalasin D (CytoD), using a dual camera video imaging system. For all pacing intervals: (1) control APDs were shorter than for CytoD but longer than for DAM; and (2) CV was greater for CytoD compared with DAM. APD dispersion increased as pacing interval decreased for both drugs. For DAM, increased dispersion was due to a difference in APD restitution between the right and left ventricle. For CytoD, increased dispersion was due to discordant alternans, with no significant spatial variation in restitution. Fibrillation was sustained only in the control hearts; with DAM, stable reentry was sustained with shorter APD and cycle length compared with CytoD for which only nonsustained unstable reentry occurred.
Conclusion: Alternans and arrhythmia dynamics are affected by the spatial dispersion of APD restitution as well as CV restitution, not simply the slope of APD restitution. Therefore, a direct link of the APD restitution slope to alternans and arrhythmia dynamics in rabbit heart does not exist. Designing antiarrhythmic drugs to alter only the restitution slope may not be appropriate.
Comment in
-
Electrical restitution and ventricular fibrillation: negotiating a slippery slope.J Cardiovasc Electrophysiol. 2002 Nov;13(11):1150-1. doi: 10.1046/j.1540-8167.2002.01150.x. J Cardiovasc Electrophysiol. 2002. PMID: 12475107 Review. No abstract available.
-
Effects of the excitation-contraction uncouplers diamine monoxime (DAM) and cytochalasin D (CytoD) on induced arrhythmias in the rabbit ventricle.J Cardiovasc Electrophysiol. 2003 Mar;14(3):331-2; author reply 332-4. J Cardiovasc Electrophysiol. 2003. PMID: 12716123 No abstract available.
Similar articles
-
Restitution dynamics during pacing and arrhythmias in isolated pig hearts.J Cardiovasc Electrophysiol. 2004 Apr;15(4):455-63. doi: 10.1046/j.1540-8167.2004.03330.x. J Cardiovasc Electrophysiol. 2004. PMID: 15089996
-
Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue.Circulation. 2000 Oct 3;102(14):1664-70. doi: 10.1161/01.cir.102.14.1664. Circulation. 2000. PMID: 11015345
-
Head-tail interactions in numerical simulations of reentry in a ring of cardiac tissue.Heart Rhythm. 2005 Aug;2(8):851-9. doi: 10.1016/j.hrthm.2005.05.012. Heart Rhythm. 2005. Corrected and republished in: Heart Rhythm. 2005 Sep;2(9):1038-46. doi: 10.1016/j.hrthm.2005.08.015. PMID: 16051124 Corrected and republished.
-
Mechanisms of arrythmogenic cardiac alternans.Europace. 2007 Nov;9 Suppl 6:vi77-82. doi: 10.1093/europace/eum210. Europace. 2007. PMID: 17959697 Review.
-
From pulsus to pulseless: the saga of cardiac alternans.Circ Res. 2006 May 26;98(10):1244-53. doi: 10.1161/01.RES.0000224540.97431.f0. Circ Res. 2006. PMID: 16728670 Review.
Cited by
-
The electrical restitution of the non-propagated cardiac ventricular action potential.Pflugers Arch. 2024 Jan;476(1):9-37. doi: 10.1007/s00424-023-02866-0. Epub 2023 Oct 3. Pflugers Arch. 2024. PMID: 37783868 Free PMC article. Review.
-
Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart.Elife. 2023 May 19;12:e84088. doi: 10.7554/eLife.84088. Elife. 2023. PMID: 37204302 Free PMC article.
-
Optical mapping of contracting hearts.J Physiol. 2023 Apr;601(8):1353-1370. doi: 10.1113/JP283683. Epub 2023 Mar 19. J Physiol. 2023. PMID: 36866700 Free PMC article. Review.
-
Cardiac Alternans: From Bedside to Bench and Back.Circ Res. 2023 Jan 6;132(1):127-149. doi: 10.1161/CIRCRESAHA.122.321668. Epub 2023 Jan 5. Circ Res. 2023. PMID: 36603066 Free PMC article. Review.
-
High-resolution in vivo monophasic gastric slow waves to quantify activation and recovery profiles.Neurogastroenterol Motil. 2022 Dec;34(12):e14422. doi: 10.1111/nmo.14422. Epub 2022 Jun 20. Neurogastroenterol Motil. 2022. PMID: 35726361 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical