Life style and occupational risk factors for bladder cancer in Germany. A case-control study
- PMID: 1551063
- DOI: 10.1002/1097-0142(19920401)69:7<1776::aid-cncr2820690721>3.0.co;2-p
Life style and occupational risk factors for bladder cancer in Germany. A case-control study
Abstract
A hospital-based, case-control study of 531 male and 144 female matched pairs was conducted in Germany to analyze the role of nonoccupational and occupational risk factors in the etiology of tumors of the lower urinary tract (bladder cancer). Smoking of cigarettes was associated with an odds ratio (OR) of 3.6 for men and 3.2 for women, compared with not smoking and showed a significant dose- and time-response relationship for both sexes. Heavy pipe smoking significantly increased the risk (OR = 1.9 in men), and smoking of cigars did not alter the risk of bladder cancer. Controlling for smoking, a significantly twofold or more increase in risk was found for heavy consumption of coffee in both sexes and for heavy intake of beer in males. Increasing levels of total fluid intake were associated with increasing, smoking-adjusted risks in men. Significant associations were found for chronic infection of the lower urinary tract (OR = 1.8), familial history of bladder cancer (OR = 2.5), and frequent consumption of high fat meals (OR = 1.4) among men and for frequent consumption of canned food in both sexes (OR = 1.7 for males, 2.4 for females). With regard to occupational history, significantly elevated odds ratios were found for ever-employment in the printing (5.0), plastics and synthetics (2.6), rubber (2.5), mining (2.0), and dyestuffs (1.9) industries, for exposure to spray paints (2.9), zinc (2.3), chromium/chromate (2.2), oils (1.5), petroleum (1.4), stone dust (1.4) and metal dust/fumes (1.3), and for occupation as mining worker (2.0) and truck driver (1.8) among men. Multivariate logistic regression analysis showed significant contribution of coffee and beer drinking, ingestion of canned food, and familial occurrence of urothelial tumors to the risk of bladder cancer in men after accounting for the effects of tobacco smoking, occupational exposures, and a history of bladder infection. These other variables did not influence the risk attributable to occupational exposures.
Similar articles
-
The association between smoking, beverage consumption, diet and bladder cancer: a systematic literature review.World J Urol. 2004 Feb;21(6):392-401. doi: 10.1007/s00345-003-0382-8. Epub 2003 Dec 17. World J Urol. 2004. PMID: 14685762 Review.
-
Bladder cancer in women.Int Urogynecol J Pelvic Floor Dysfunct. 1999;10(3):207-12. doi: 10.1007/s001920050046. Int Urogynecol J Pelvic Floor Dysfunct. 1999. PMID: 10430016 Review.
-
[Etiology, pathogenesis and epidemiology or urothelial tumors].Verh Dtsch Ges Pathol. 1993;77:147-56. Verh Dtsch Ges Pathol. 1993. PMID: 7511274 German.
-
Life-style and occupational risk factors in cancer of the lower urinary tract.Am J Epidemiol. 1986 Oct;124(4):578-89. doi: 10.1093/oxfordjournals.aje.a114430. Am J Epidemiol. 1986. PMID: 3752052
-
Occupation and risk of cancer of the lower urinary tract among men. A case-control study.Int J Cancer. 1988 Mar 15;41(3):371-9. doi: 10.1002/ijc.2910410309. Int J Cancer. 1988. PMID: 3346100
Cited by
-
Does the urinary microbiome profile change after treatment of bladder cancer?World J Urol. 2023 Dec;41(12):3593-3598. doi: 10.1007/s00345-023-04627-1. Epub 2023 Oct 5. World J Urol. 2023. PMID: 37796319
-
The Urinary Microbiome and Bladder Cancer.Life (Basel). 2023 Mar 17;13(3):812. doi: 10.3390/life13030812. Life (Basel). 2023. PMID: 36983967 Free PMC article. Review.
-
Occupational Mortality Matrix: A Tool for Epidemiological Assessment of Work-Related Risk Based on Current Data Sources.Int J Environ Res Public Health. 2022 May 6;19(9):5652. doi: 10.3390/ijerph19095652. Int J Environ Res Public Health. 2022. PMID: 35565047 Free PMC article.
-
The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer.Genes Dis. 2020 Oct 13;8(6):781-797. doi: 10.1016/j.gendis.2020.10.002. eCollection 2021 Nov. Genes Dis. 2020. PMID: 34522708 Free PMC article. Review.
-
Bladder cancer risk associated with family history of cancer.Int J Cancer. 2021 Jun 15;148(12):2915-2923. doi: 10.1002/ijc.33486. Epub 2021 Mar 5. Int J Cancer. 2021. PMID: 33506540 Free PMC article.