Delineation of the function of a major gamma delta T cell subset during infection
- PMID: 16034115
- DOI: 10.4049/jimmunol.175.3.1741
Delineation of the function of a major gamma delta T cell subset during infection
Abstract
Gammadelta T cells play important but poorly defined roles in pathogen-induced immune responses and in preventing chronic inflammation and pathology. A major obstacle to defining their function is establishing the degree of functional redundancy and heterogeneity among gammadelta T cells. Using mice deficient in Vgamma1+ T cells which are a major component of the gammadelta T cell response to microbial infection, a specific immunoregulatory role for Vgamma1+ T cells in macrophage and gammadelta T cell homeostasis during infection has been established. By contrast, Vgamma1+ T cells play no significant role in pathogen containment or eradication and cannot protect mice from immune-mediated pathology. Pathogen-elicited Vgamma1+ T cells also display different functional characteristics at different stages of the host response to infection that involves unique and different populations of Vgamma1+ T cells. These findings, therefore, identify distinct and nonoverlapping roles for gammadelta T cell subsets in infection and establish the complexity and adaptability of a single population of gammadelta T cells in the host response to infection that is not predetermined, but is, instead, shaped by environmental factors.
Similar articles
-
γδ T Lymphocytes in Asthma: a Complicated Picture.Arch Immunol Ther Exp (Warsz). 2021 Mar 4;69(1):4. doi: 10.1007/s00005-021-00608-7. Arch Immunol Ther Exp (Warsz). 2021. PMID: 33661375 Free PMC article. Review.
-
Antigen-independent priming: a transitional response of bovine gammadelta T-cells to infection.Anim Health Res Rev. 2008 Jun;9(1):47-57. doi: 10.1017/S1466252307001363. Epub 2008 Mar 17. Anim Health Res Rev. 2008. PMID: 18346297 Review.
-
Fas-Fas ligand interactions are essential for the binding to and killing of activated macrophages by gamma delta T cells.J Immunol. 2004 Sep 15;173(6):3660-7. doi: 10.4049/jimmunol.173.6.3660. J Immunol. 2004. PMID: 15356111
-
The interaction of gamma delta T cells with activated macrophages is a property of the V gamma 1 subset.J Immunol. 2003 Dec 15;171(12):6488-94. doi: 10.4049/jimmunol.171.12.6488. J Immunol. 2003. PMID: 14662848
-
Depletion of a gamma delta T cell subset can increase host resistance to a bacterial infection.J Immunol. 2000 Dec 1;165(11):6472-9. doi: 10.4049/jimmunol.165.11.6472. J Immunol. 2000. PMID: 11086087
Cited by
-
Sex-Related Effect of Aging in Gingival Gamma-Delta T Cells.J Dent Res. 2024 Jan;103(1):62-70. doi: 10.1177/00220345231205210. Epub 2023 Nov 15. J Dent Res. 2024. PMID: 37968805
-
A Distinctive γδ T Cell Repertoire in NOD Mice Weakens Immune Regulation and Favors Diabetic Disease.Biomolecules. 2022 Oct 1;12(10):1406. doi: 10.3390/biom12101406. Biomolecules. 2022. PMID: 36291615 Free PMC article.
-
IL-4-Producing Vγ1+/Vδ6+ γδ T Cells Sustain Germinal Center Reactions in Peyer's Patches of Mice.Front Immunol. 2021 Nov 3;12:729607. doi: 10.3389/fimmu.2021.729607. eCollection 2021. Front Immunol. 2021. PMID: 34804014 Free PMC article.
-
β2 Integrins differentially regulate γδ T cell subset thymic development and peripheral maintenance.Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22367-22377. doi: 10.1073/pnas.1921930117. Epub 2020 Aug 26. Proc Natl Acad Sci U S A. 2020. PMID: 32848068 Free PMC article.
-
Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells.Front Immunol. 2018 Nov 27;9:2636. doi: 10.3389/fimmu.2018.02636. eCollection 2018. Front Immunol. 2018. PMID: 30538697 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases