On the road to cancer: aneuploidy and the mitotic checkpoint
- PMID: 16195750
- DOI: 10.1038/nrc1714
On the road to cancer: aneuploidy and the mitotic checkpoint
Abstract
Abnormal chromosome content - also known as aneuploidy - is the most common characteristic of human solid tumours. It has therefore been proposed that aneuploidy contributes to, or even drives, tumour development. The mitotic checkpoint guards against chromosome mis-segregation by delaying cell-cycle progression through mitosis until all chromosomes have successfully made spindle-microtubule attachments. Defects in the mitotic checkpoint generate aneuploidy and might facilitate tumorigenesis, but more severe disabling of checkpoint signalling is a possible anticancer strategy.
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