Review
doi: 10.1038/nrc1714.
On the road to cancer: aneuploidy and the mitotic checkpoint
Affiliations
- PMID: 16195750
- DOI: 10.1038/nrc1714
Item in Clipboard
Review
On the road to cancer: aneuploidy and the mitotic checkpoint
Nat Rev Cancer.
2005 Oct.
Abstract
Abnormal chromosome content - also known as aneuploidy - is the most common characteristic of human solid tumours. It has therefore been proposed that aneuploidy contributes to, or even drives, tumour development. The mitotic checkpoint guards against chromosome mis-segregation by delaying cell-cycle progression through mitosis until all chromosomes have successfully made spindle-microtubule attachments. Defects in the mitotic checkpoint generate aneuploidy and might facilitate tumorigenesis, but more severe disabling of checkpoint signalling is a possible anticancer strategy.
Similar articles
-
How mitotic errors contribute to karyotypic diversity in cancer.Adv Cancer Res. 2011;112:43-75. doi: 10.1016/B978-0-12-387688-1.00003-X. Adv Cancer Res. 2011. PMID: 21925301 Review.
-
The spindle assembly checkpoint: preventing chromosome mis-segregation during mitosis and meiosis.FEBS Lett. 2006 May 22;580(12):2888-95. doi: 10.1016/j.febslet.2006.03.081. Epub 2006 Apr 7. FEBS Lett. 2006. PMID: 16631173 Review.
-
Causes of Chromosomal Instability.Recent Results Cancer Res. 2015;200:95-113. doi: 10.1007/978-3-319-20291-4_5. Recent Results Cancer Res. 2015. PMID: 26376874 Review.
-
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis.Nat Rev Mol Cell Biol. 2009 Jul;10(7):478-87. doi: 10.1038/nrm2718. Nat Rev Mol Cell Biol. 2009. PMID: 19546858 Free PMC article. Review.
-
Preventing aneuploidy: the contribution of mitotic checkpoint proteins.Biochim Biophys Acta. 2008 Sep;1786(1):24-31. doi: 10.1016/j.bbcan.2008.04.001. Epub 2008 Apr 22. Biochim Biophys Acta. 2008. PMID: 18472014 Review.
Cited by
-
Correlation of BUB1 and BUB1B with the development and prognosis of endometrial cancer.Sci Rep. 2024 Jul 24;14(1):17084. doi: 10.1038/s41598-024-67528-2. Sci Rep. 2024. PMID: 39048649 Free PMC article.
-
Exosomal miR-493 suppresses MAD2L1 and induces chemoresistance to intraperitoneal paclitaxel therapy in gastric cancer patients with peritoneal metastasis.Sci Rep. 2024 May 2;14(1):10075. doi: 10.1038/s41598-024-60967-x. Sci Rep. 2024. PMID: 38698201 Free PMC article.
-
Kinesin-7 CENP-E in tumorigenesis: Chromosome instability, spindle assembly checkpoint, and applications.Front Mol Biosci. 2024 Mar 15;11:1366113. doi: 10.3389/fmolb.2024.1366113. eCollection 2024. Front Mol Biosci. 2024. PMID: 38560520 Free PMC article. Review.
-
CCNA2 and NEK2 regulate glioblastoma progression by targeting the cell cycle.Oncol Lett. 2024 Mar 13;27(5):206. doi: 10.3892/ol.2024.14339. eCollection 2024 May. Oncol Lett. 2024. PMID: 38516683 Free PMC article.
-
Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important?Int J Mol Sci. 2024 Feb 9;25(4):2101. doi: 10.3390/ijms25042101. Int J Mol Sci. 2024. PMID: 38396778 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
