Low-density lipoprotein size and cardiovascular risk assessment
- PMID: 16371404
- DOI: 10.1093/qjmed/hci154
Low-density lipoprotein size and cardiovascular risk assessment
Erratum in
- QJM. 2007 Feb;100(2):147
Abstract
A predominance of small, dense low-density lipoproteins (LDL) has been accepted as an emerging cardiovascular risk factor by the National Cholesterol Education Program Adult Treatment Panel III. LDL size seems to be an important predictor of cardiovascular events and progression of coronary heart disease and evidences suggests that both quality (particularly small, dense LDL) and quantity may increase cardiovascular risk. However, other authors have suggested that LDL size measurement does not add information beyond that obtained by measuring LDL concentration, triglyceride levels and HDL concentrations. Therefore, it remains debatable whether to measure LDL particle size in cardiovascular risk assessment and, if so, in which categories of patient. Therapeutic modulation of LDL particle size or number appears beneficial in reducing the risk of cardiovascular events, but no clear causal relationship has been shown, because of confounding factors, including lipid and non-lipid variables. Studies are needed to investigate the clinical significance of LDL size measurements in patients with coronary and non-coronary forms of atherosclerosis; in particular, to test whether LDL size is associated with even higher vascular risk, and whether LDL size modification may contribute to secondary prevention in such patients.
Similar articles
-
Who needs to care about small, dense low-density lipoproteins?Int J Clin Pract. 2007 Nov;61(11):1949-56. doi: 10.1111/j.1742-1241.2007.01596.x. Int J Clin Pract. 2007. PMID: 17935554 Review.
-
Small, dense low-density-lipoproteins and the metabolic syndrome.Diabetes Metab Res Rev. 2007 Jan;23(1):14-20. doi: 10.1002/dmrr.694. Diabetes Metab Res Rev. 2007. PMID: 17080469 Review.
-
The significance of low-density-lipoproteins size in vascular diseases.Int Angiol. 2006 Mar;25(1):4-9. Int Angiol. 2006. PMID: 16520717 Review.
-
Low-density lipoprotein size and cardiovascular prevention.Eur J Intern Med. 2006 Mar;17(2):77-80. doi: 10.1016/j.ejim.2005.08.013. Eur J Intern Med. 2006. PMID: 16490681
-
Should we measure routinely the LDL peak particle size?Int J Cardiol. 2006 Feb 15;107(2):166-70. doi: 10.1016/j.ijcard.2005.02.035. Int J Cardiol. 2006. PMID: 16412793 Review.
Cited by
-
The association of appendicular lean mass and grip strength with low-density lipoprotein, very low-density lipoprotein, and high-density lipoprotein particle diameter: a Mendelian randomization study of the UK Biobank cohort.Eur Heart J Open. 2024 Mar 14;4(2):oeae019. doi: 10.1093/ehjopen/oeae019. eCollection 2024 Mar. Eur Heart J Open. 2024. PMID: 38595990 Free PMC article.
-
New Advances in Rapid Pretreatment for Small Dense LDL Cholesterol Measurement Using Shear Horizontal Surface Acoustic Wave (SH-SAW) Technology.Int J Mol Sci. 2024 Jan 15;25(2):1044. doi: 10.3390/ijms25021044. Int J Mol Sci. 2024. PMID: 38256117 Free PMC article.
-
Comparative Evaluation of a Low-Carbohydrate Diet and a Mediterranean Diet in Overweight/Obese Patients with Type 2 Diabetes Mellitus: A 16-Week Intervention Study.Nutrients. 2023 Dec 27;16(1):95. doi: 10.3390/nu16010095. Nutrients. 2023. PMID: 38201924 Free PMC article.
-
Lipoproteins and Their Effects on the Cardiovascular System.Cureus. 2023 Nov 15;15(11):e48865. doi: 10.7759/cureus.48865. eCollection 2023 Nov. Cureus. 2023. PMID: 38106760 Free PMC article. Review.
-
Dyslipidemia in rheumatoid arthritis: the possible mechanisms.Front Immunol. 2023 Oct 25;14:1254753. doi: 10.3389/fimmu.2023.1254753. eCollection 2023. Front Immunol. 2023. PMID: 37954591 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources