Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells
- PMID: 16872154
- DOI: 10.1021/np060081y
Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells
Abstract
A bioassay-guided phytochemical investigation on the methanol extract of Boehmeria pannosa, using a HIF-1-mediated reporter gene assay, led to the isolation of two phenanthroquinolizidine alkaloids, (-)-cryptopleurine (1) and (-)-(15R)-hydroxycryptopleurine (2). The structure of the new compound 2 was determined by spectroscopic methods. Compounds 1 and 2 potently inhibited the hypoxia-induced expression of a reporter gene under the control of a hypoxia response element (HRE) with IC(50) values of 8.7 and 48.1 nM, respectively. Furthermore, 1 and 2 suppressed the accumulation of HIF-1alpha protein in a dose-dependent manner, but not the HIF-1beta protein and inhibited expression of vascular endothelial growth factor (VEGF) by hypoxia.
Similar articles
-
Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1.J Nat Prod. 2007 Jul;70(7):1093-7. doi: 10.1021/np060482d. Epub 2007 Jun 21. J Nat Prod. 2007. PMID: 17583950
-
An isoaurone and other constituents from Trichosanthes kirilowii seeds inhibit hypoxia-inducible factor-1 and nuclear factor-kappaB.J Nat Prod. 2010 Jun 25;73(6):1167-9. doi: 10.1021/np900820p. J Nat Prod. 2010. PMID: 20469887
-
Molecular-targeted antitumor agents: the Saururus cernuus dineolignans manassantin B and 4-O-demethylmanassantin B are potent inhibitors of hypoxia-activated HIF-1.J Nat Prod. 2004 May;67(5):767-71. doi: 10.1021/np030514m. J Nat Prod. 2004. PMID: 15165135
-
Hypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived diels-alder adducts from Morus species.J Nat Prod. 2009 Jan;72(1):39-43. doi: 10.1021/np800491u. J Nat Prod. 2009. PMID: 19072214
-
Is the hypoxia-inducible factor pathway important in gastric cancer?Eur J Cancer. 2005 Dec;41(18):2792-805. doi: 10.1016/j.ejca.2005.09.008. Epub 2005 Nov 14. Eur J Cancer. 2005. PMID: 16290133 Review.
Cited by
-
Potential applications of antofine and its synthetic derivatives in cancer therapy: structural and molecular insights.Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun 6. doi: 10.1007/s00210-024-03180-x. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38842561 Review.
-
Isolation of GLP-1 enhancing indolizidine alkaloids from Boehmeria formosana.J Food Drug Anal. 2023 Dec 15;31(4):739-771. doi: 10.38212/2224-6614.3483. J Food Drug Anal. 2023. PMID: 38526826 Free PMC article.
-
Quinolizidine-Type Alkaloids: Chemodiversity, Occurrence, and Bioactivity.ACS Omega. 2023 Jul 28;8(31):27862-27893. doi: 10.1021/acsomega.3c02179. eCollection 2023 Aug 8. ACS Omega. 2023. PMID: 37576649 Free PMC article. Review.
-
Possible pharmaceutical applications can be developed from naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids.Phytochem Rev. 2021;20(4):845-868. doi: 10.1007/s11101-020-09723-3. Epub 2020 Sep 25. Phytochem Rev. 2021. PMID: 32994757 Free PMC article. Review.
-
Extract of Boehmeria nivea Suppresses Mast Cell-Mediated Allergic Inflammation by Inhibiting Mitogen-Activated Protein Kinase and Nuclear Factor-κB.Molecules. 2020 Sep 12;25(18):4178. doi: 10.3390/molecules25184178. Molecules. 2020. PMID: 32932637 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Chemical Information
Medical
