Mediterranean dietary pattern and prediction of all-cause mortality in a US population: results from the NIH-AARP Diet and Health Study
- PMID: 18071168
- DOI: 10.1001/archinte.167.22.2461
Mediterranean dietary pattern and prediction of all-cause mortality in a US population: results from the NIH-AARP Diet and Health Study
Abstract
Background: The Mediterranean diet has been suggested to play a beneficial role for health and longevity. However, to our knowledge, no prospective US study has investigated the Mediterranean dietary pattern in relation to mortality.
Methods: Study participants included 214,284 men and 166,012 women in the National Institutes of Health (NIH)-AARP (formerly known as the American Association of Retired Persons) Diet and Health Study. During follow-up for all-cause mortality (1995-2005), 27,799 deaths were documented. In the first 5 years of follow-up, 5,985 cancer deaths and 3,451 cardiovascular disease (CVD) deaths were reported. We used a 9-point score to assess conformity with the Mediterranean dietary pattern (components included vegetables, legumes, fruits, nuts, whole grains, fish, monounsaturated fat-saturated fat ratio, alcohol, and meat). We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) using age- and multivariate-adjusted Cox models.
Results: The Mediterranean diet was associated with reduced all-cause and cause-specific mortality. In men, the multivariate HRs comparing high to low conformity for all-cause, CVD, and cancer mortality were 0.79 (95% CI, 0.76-0.83), 0.78 (95% CI, 0.69-0.87), and 0.83 (95% CI, 0.76-0.91), respectively. In women, an inverse association was seen with high conformity with this pattern: decreased risks that ranged from 12% for cancer mortality to 20% for all-cause mortality (P = .04 and P < .001, respectively, for the trend). When we restricted our analyses to never smokers, associations were virtually unchanged.
Conclusion: These results provide strong evidence for a beneficial effect of higher conformity with the Mediterranean dietary pattern on risk of death from all causes, including deaths due to CVD and cancer, in a US population.
Comment in
-
Mediterranean diet and mortality in a US population.Arch Intern Med. 2008 Sep 8;168(16):1823-4. doi: 10.1001/archinte.168.16.1823. Arch Intern Med. 2008. PMID: 18779472 Free PMC article. No abstract available.
Similar articles
-
Combined associations of body mass index and adherence to a Mediterranean-like diet with all-cause and cardiovascular mortality: A cohort study.PLoS Med. 2020 Sep 17;17(9):e1003331. doi: 10.1371/journal.pmed.1003331. eCollection 2020 Sep. PLoS Med. 2020. PMID: 32941436 Free PMC article.
-
Higher diet quality is associated with decreased risk of all-cause, cardiovascular disease, and cancer mortality among older adults.J Nutr. 2014 Jun;144(6):881-9. doi: 10.3945/jn.113.189407. Epub 2014 Feb 26. J Nutr. 2014. PMID: 24572039 Free PMC article.
-
Mediterranean diet and cardiovascular disease: historical perspective and latest evidence.Curr Atheroscler Rep. 2013 Dec;15(12):370. doi: 10.1007/s11883-013-0370-4. Curr Atheroscler Rep. 2013. PMID: 24105622 Review.
-
Meat intake and mortality: a prospective study of over half a million people.Arch Intern Med. 2009 Mar 23;169(6):562-71. doi: 10.1001/archinternmed.2009.6. Arch Intern Med. 2009. PMID: 19307518 Free PMC article.
-
Adherence to Mediterranean diet and health status: meta-analysis.BMJ. 2008 Sep 11;337:a1344. doi: 10.1136/bmj.a1344. BMJ. 2008. PMID: 18786971 Free PMC article. Review.
Cited by
-
Mediterranean Diet Adherence and Risk of All-Cause Mortality in Women.JAMA Netw Open. 2024 May 1;7(5):e2414322. doi: 10.1001/jamanetworkopen.2024.14322. JAMA Netw Open. 2024. PMID: 38819819 Free PMC article.
-
Associations between the gut microbiome, gut microbiology and heart failure: Current understanding and future directions.Am Heart J Plus. 2022 Jun 11;17:100150. doi: 10.1016/j.ahjo.2022.100150. eCollection 2022 May. Am Heart J Plus. 2022. PMID: 38559891 Free PMC article. Review.
-
Review of dietary patterns and gastric cancer risk: epidemiology and biological evidence.Front Oncol. 2024 Feb 20;14:1333623. doi: 10.3389/fonc.2024.1333623. eCollection 2024. Front Oncol. 2024. PMID: 38444674 Free PMC article. Review.
-
Pre-diagnosis dietary patterns and risk of multiple myeloma in the NIH-AARP diet and health study.Leukemia. 2024 Feb;38(2):438-441. doi: 10.1038/s41375-023-02132-3. Epub 2023 Dec 29. Leukemia. 2024. PMID: 38158443 Free PMC article. No abstract available.
-
Exploring Benefits and Barriers of Plant-Based Diets: Health, Environmental Impact, Food Accessibility and Acceptability.Nutrients. 2023 Nov 8;15(22):4723. doi: 10.3390/nu15224723. Nutrients. 2023. PMID: 38004117 Free PMC article. Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources