Folate, vitamin B6, vitamin B12, and methionine intakes and risk of stroke subtypes in male smokers
- PMID: 18270369
- DOI: 10.1093/aje/kwm395
Folate, vitamin B6, vitamin B12, and methionine intakes and risk of stroke subtypes in male smokers
Abstract
The associations of dietary folate, vitamin B(6), vitamin B(12), and methionine intakes with risk of stroke subtypes were examined among 26,556 male Finnish smokers, aged 50-69 years, enrolled in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Dietary intake was assessed at baseline by using a validated food frequency questionnaire. During a mean follow-up of 13.6 years, from 1985 through 2004, 2,702 cerebral infarctions, 383 intracerebral hemorrhages, and 196 subarachnoid hemorrhages were identified from national registers. In analyses adjusting for age and cardiovascular risk factors, a high folate intake was associated with a statistically significant lower risk of cerebral infarction but not intracerebral or subarachnoid hemorrhages. The multivariate relative risk of cerebral infarction was 0.80 (95% confidence interval: 0.70, 0.91; p(trend) = 0.001) for men in the highest versus lowest quintile of folate intake. Vitamin B(6), vitamin B(12), and methionine intakes were not significantly associated with any subtype of stroke. These findings in men suggest that a high dietary folate intake may reduce the risk of cerebral infarction.
Similar articles
-
Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.Eur J Clin Nutr. 2023 Mar;77(3):299-307. doi: 10.1038/s41430-022-01206-2. Epub 2022 Sep 13. Eur J Clin Nutr. 2023. PMID: 36100703 Review.
-
Dietary folate, vitamin B6, vitamin B12 and methionine intake and the risk of breast cancer by oestrogen and progesterone receptor status.Br J Nutr. 2011 Sep;106(6):936-43. doi: 10.1017/S0007114511001140. Epub 2011 May 16. Br J Nutr. 2011. PMID: 21736840
-
Folate, vitamin B6, and B12 intakes in relation to risk of stroke among men.Stroke. 2004 Jan;35(1):169-74. doi: 10.1161/01.STR.0000106762.55994.86. Epub 2003 Dec 11. Stroke. 2004. PMID: 14671243
-
Folate, vitamin B6, vitamin B12 and methionine intakes and risk for nasopharyngeal carcinoma in Chinese adults: a matched case-control study.Br J Nutr. 2016 Jan 14;115(1):121-8. doi: 10.1017/S0007114515004146. Epub 2015 Oct 30. Br J Nutr. 2016. PMID: 26515433
-
Heterogeneity and lack of good quality studies limit association between folate, vitamins B-6 and B-12, and cognitive function.J Nutr. 2007 Jul;137(7):1789-94. doi: 10.1093/jn/137.7.1789. J Nutr. 2007. PMID: 17585032 Review.
Cited by
-
Dietary vitamin B6 intake and stroke are negatively associated in adults: A cross-sectional study from the NHANES.Heliyon. 2024 May 11;10(10):e31125. doi: 10.1016/j.heliyon.2024.e31125. eCollection 2024 May 30. Heliyon. 2024. PMID: 38778939 Free PMC article.
-
The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment.Nutrients. 2023 Nov 3;15(21):4662. doi: 10.3390/nu15214662. Nutrients. 2023. PMID: 37960316 Free PMC article. Review.
-
Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.Eur J Clin Nutr. 2023 Mar;77(3):299-307. doi: 10.1038/s41430-022-01206-2. Epub 2022 Sep 13. Eur J Clin Nutr. 2023. PMID: 36100703 Review.
-
Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease.Front Cardiovasc Med. 2021 Feb 24;8:632131. doi: 10.3389/fcvm.2021.632131. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 33718454 Free PMC article. Review.
-
Dietary Intake of Homocysteine Metabolism-Related B-Vitamins and the Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies.Adv Nutr. 2020 Nov 16;11(6):1510-1528. doi: 10.1093/advances/nmaa061. Adv Nutr. 2020. PMID: 32503038 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical