Extremely high mutation rate of a hammerhead viroid
- PMID: 19265013
- DOI: 10.1126/science.1169202
Extremely high mutation rate of a hammerhead viroid
Abstract
The mutation rates of viroids, plant pathogens with minimal non-protein-coding RNA genomes, are unknown. Their replication is mediated by host RNA polymerases and, in some cases, by hammerhead ribozymes, small self-cleaving motifs embedded in the viroid. By using the principle that the population frequency of nonviable genotypes equals the mutation rate, we screened for changes that inactivated the hammerheads of Chrysanthemum chlorotic mottle viroid. We obtained a mutation rate of 1/400 per site, the highest reported for any biological entity. Such error-prone replication can only be tolerated by extremely simple genomes such as those of viroids and, presumably, the primitive replicons of the RNA world. Our results suggest that the emergence of replication fidelity was critical for the evolution of complexity in the early history of life.
Similar articles
-
Viroids: the minimal non-coding RNAs with autonomous replication.FEBS Lett. 2004 Jun 1;567(1):42-8. doi: 10.1016/j.febslet.2004.03.118. FEBS Lett. 2004. PMID: 15165891 Review.
-
One-step site-directed mutagenesis of viroid dimeric cDNA.J Virol Methods. 2007 Oct;145(1):71-5. doi: 10.1016/j.jviromet.2007.05.027. Epub 2007 Jun 29. J Virol Methods. 2007. PMID: 17604131
-
High-pressure analysis of a hammerhead ribozyme from Chrysanthemum chlorotic mottle viroid reveals two different populations of self-cleaving molecule.FEBS J. 2011 Oct;278(19):3739-47. doi: 10.1111/j.1742-4658.2011.08291.x. Epub 2011 Sep 6. FEBS J. 2011. PMID: 21824288
-
Viroids: survivors from the RNA world?Annu Rev Microbiol. 2014;68:395-414. doi: 10.1146/annurev-micro-091313-103416. Epub 2014 Jun 18. Annu Rev Microbiol. 2014. PMID: 25002087 Review.
-
Viroids: unusual small pathogenic RNAs.Acta Biochim Pol. 2004;51(3):587-607. Acta Biochim Pol. 2004. PMID: 15448723 Review.
Cited by
-
Viral Metatranscriptomic Analysis to Reveal the Diversity of Viruses Infecting Satsuma Mandarin (Citrus unshiu) in Korea.Plant Pathol J. 2024 Apr;40(2):115-124. doi: 10.5423/PPJ.OA.01.2024.0009. Epub 2024 Apr 1. Plant Pathol J. 2024. PMID: 38606442 Free PMC article.
-
RNA three-dimensional structure drives the sequence organization of potato spindle tuber viroid quasispecies.PLoS Pathog. 2024 Apr 4;20(4):e1012142. doi: 10.1371/journal.ppat.1012142. eCollection 2024 Apr. PLoS Pathog. 2024. PMID: 38574111 Free PMC article.
-
Viroids, Satellite RNAs and Prions: Folding of Nucleic Acids and Misfolding of Proteins.Viruses. 2024 Feb 26;16(3):360. doi: 10.3390/v16030360. Viruses. 2024. PMID: 38543726 Free PMC article.
-
Viroid-like colonists of human microbiomes.bioRxiv [Preprint]. 2024 Jan 21:2024.01.20.576352. doi: 10.1101/2024.01.20.576352. bioRxiv. 2024. PMID: 38293115 Free PMC article. Preprint.
-
Cell-cell communication and initial population composition shape the structure of potato spindle tuber viroid quasispecies.Plant Cell. 2024 Mar 29;36(4):1036-1055. doi: 10.1093/plcell/koae012. Plant Cell. 2024. PMID: 38252648
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources