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Review
. 2009 Jun;10(6):423-33.
doi: 10.1038/nrn2651.

Stress, memory and the amygdala

Benno Roozendaal  1 , Bruce S McEwen, Sumantra Chattarji
Affiliations
Review

Stress, memory and the amygdala

Benno Roozendaal et al. Nat Rev Neurosci. 2009 Jun.

Abstract

Emotionally significant experiences tend to be well remembered, and the amygdala has a pivotal role in this process. But the efficient encoding of emotional memories can become maladaptive - severe stress often turns them into a source of chronic anxiety. Here, we review studies that have identified neural correlates of stress-induced modulation of amygdala structure and function - from cellular mechanisms to their behavioural consequences. The unique features of stress-induced plasticity in the amygdala, in association with changes in other brain regions, could have long-term consequences for cognitive performance and pathological anxiety exhibited in people with affective disorders.

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