doi: 10.1016/s0022-5193(05)80465-5.
The effects of discrete gap junction coupling on propagation in myocardium
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- PMID: 2016885
- DOI: 10.1016/s0022-5193(05)80465-5
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The effects of discrete gap junction coupling on propagation in myocardium
J Theor Biol.
.
Abstract
A modified cable theory for a bi-domain model of myocardium that incorporates the effect of gap junctions as discrete objects coupling cardiac cells is derived. The theory is shown to be in agreement with a number of experiments that cannot be explained using standard continuous cable theory, and resolves some apparent contradictions on failure of propagation in two-dimensional anisotropic tissue. In addition, some as yet untested predictions of the theory are mentioned.
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