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Review
. 2010 Jul;155(7):1021-31.
doi: 10.1007/s00705-010-0691-3. Epub 2010 May 12.

Viral interaction with molecular chaperones: role in regulating viral infection

Allen Xiao  1 , Jerry Wong, Honglin Luo
Affiliations
Review

Viral interaction with molecular chaperones: role in regulating viral infection

Allen Xiao et al. Arch Virol. 2010 Jul.

Abstract

As essential effectors in protein quality control, molecular chaperones serve as the primary checkpoint to assist proper protein folding and prevent misfolded proteins from denaturation and aggregation. In addition, chaperones can function to direct terminally misfolded proteins to the proteolytic system for degradation. Viruses rely on host cell machineries for productive infection. Like for many other processes, various viruses have been shown to evolve mechanisms to utilize or subvert the host protein quality control machinery to support the completion of their life cycle. Furthermore, recent studies suggest that some viruses encode for their own chaperone-like proteins to enhance their infectivity. This review summarizes the current understanding of the interplay between molecular chaperones and viral proteins, highlights the chaperone activities of a number of viral proteins, and discusses potential antiviral therapeutic strategies targeting the virus-chaperone interactions.

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