Difluorotetrahydropyridothiazinone: a selective β-galactosidase inhibitor
- PMID: 20925095
- DOI: 10.1002/ardp.200900307
Difluorotetrahydropyridothiazinone: a selective β-galactosidase inhibitor
Abstract
Selective difluorination, introducing a lactame moiety (instead of an amine) and a double bond in a trihydroxy-2-thiaquinolizidine derivative reverses the selectivity of the glycosidase inhibitor - a selective inhibitor for an α-glucosidase is altered into an excellent, competitive inhibitor for a β-galactosidase.
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