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Review
. 2011 Apr;43(4):248-57.
doi: 10.1093/abbs/gmr007. Epub 2011 Feb 16.

PGC-1 coactivators in the control of energy metabolism

Chang Liu  1 , Jiandie D Lin
Affiliations
Review

PGC-1 coactivators in the control of energy metabolism

Chang Liu et al. Acta Biochim Biophys Sin (Shanghai). 2011 Apr.

Abstract

Chronic disruption of energy balance, where energy intake exceeds expenditure, is a major risk factor for the development of metabolic syndrome. The latter is characterized by a constellation of symptoms including obesity, dyslipidemia, insulin resistance, hypertension, and non-alcoholic fatty liver disease. Altered expression of genes involved in glucose and lipid metabolism as well as mitochondrial oxidative phosphorylation has been implicated in the pathogenesis of these disorders. The peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) family of transcriptional coactivators is emerging as a hub linking nutritional and hormonal signals and energy metabolism. PGC-1α and PGC-1β are highly responsive to environmental cues and coordinate metabolic gene programs through interaction with transcription factors and chromatin-remodeling proteins. PGC-1α has been implicated in the pathogenic conditions including obesity, type 2 diabetes, neurodegeneration, and cardiomyopathy, whereas PGC-1β plays an important role in plasma lipoprotein homeostasis and serves as a hepatic target for niacin, a potent hypotriglyceridemic drug. Here, we review recent advances in the identification of physiological and pathophysiological contexts involving PGC-1 coactivators, and also discuss their implications for therapeutic development.

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Figures

Figure 1
Figure 1
The working model of PGC-1 coactivators PGC-1α and PGC-1β regulate diverse metabolic programs through coactivating selective transcriptional factors (TF) associated with regulatory elements of target genes. PGC-1 recruits HAT, SWI/SNF chromatin-remodeling, Sirt1 deacetylase, and mediator complexes to modulate the epigenetic status of chromatin.
See this image and copyright information in PMC

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