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. 2012 Jul 21;380(9838):219-29.
doi: 10.1016/S0140-6736(12)61031-9.

Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy

I-Min Lee  1 , Eric J Shiroma, Felipe Lobelo, Pekka Puska, Steven N Blair, Peter T Katzmarzyk; Lancet Physical Activity Series Working Group
Collaborators, Affiliations

Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy

I-Min Lee et al. Lancet. .

Abstract

Background: Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including major non-communicable diseases such as coronary heart disease, type 2 diabetes, and breast and colon cancers, and shortens life expectancy. Because much of the world's population is inactive, this link presents a major public health issue. We aimed to quantify the eff ect of physical inactivity on these major non-communicable diseases by estimating how much disease could be averted if inactive people were to become active and to estimate gain in life expectancy at the population level.

Methods: For our analysis of burden of disease, we calculated population attributable fractions (PAFs) associated with physical inactivity using conservative assumptions for each of the major non-communicable diseases, by country, to estimate how much disease could be averted if physical inactivity were eliminated. We used life-table analysis to estimate gains in life expectancy of the population.

Findings: Worldwide, we estimate that physical inactivity causes 6% (ranging from 3·2% in southeast Asia to 7·8% in the eastern Mediterranean region) of the burden of disease from coronary heart disease, 7% (3·9-9·6) of type 2 diabetes, 10% (5·6-14·1) of breast cancer, and 10% (5·7-13·8) of colon cancer. Inactivity causes 9% (range 5·1-12·5) of premature mortality, or more than 5·3 million of the 57 million deaths that occurred worldwide in 2008. If inactivity were not eliminated, but decreased instead by 10% or 25%, more than 533 000 and more than 1·3 million deaths, respectively, could be averted every year. We estimated that elimination of physical inactivity would increase the life expectancy of the world's population by 0·68 (range 0·41-0·95) years.

Interpretation: Physical inactivity has a major health eff ect worldwide. Decrease in or removal of this unhealthy behaviour could improve health substantially.

Funding: None.

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Conflict of interest statement

Conflicts of Interest

We declare that we have no conflicts of interest. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

Figures

Figure 1
Figure 1
Health benefits of physical activity in adults–
Figure 2
Figure 2
Formulae for calculating population attributable fraction (PAF)
Figure 3
Figure 3
Map of the world showing estimated gains in life expectancy with elimination of physical inactivity
See this image and copyright information in PMC

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References

    1. Rook A. An investigation into the longevity of Cambridge sportsmen. Br Med J. 1954;1:773–7. - PMC - PubMed
    1. Blair SN, Davey Smith G, Lee IM, Fox K, Hillsdon M, McKeown RE, et al. A tribute to Professor Jeremiah Morris: the man who invented the field of physical activity epidemiology. Ann Epidemiol. 2011;20:651–60. - PubMed
    1. U.S. Department of Health & Human Services. Physical Activity Guidelines Advisory Committee report. 2008 [cited 1 September 2011]; Available from: http://www.health.gov/paguidelines/
    1. Warburton DE, Charlesworth S, Ivey A, Nettlefold L, Bredin SS. A systematic review of the evidence for Canada’s Physical Activity Guidelines for Adults. The international journal of behavioral nutrition and physical activity. 2010;7:39. - PMC - PubMed
    1. World Health Organization. Global recommendations on physical activity for health. Geneva, Switzerland: WHO; 2010. - PubMed

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