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. 2013 Jun 12;8(6):e65968.
doi: 10.1371/journal.pone.0065968. Print 2013.

Mitochondrial DNA copy number is associated with breast cancer risk

Bharat Thyagarajan  1 , Renwei Wang, Heather Nelson, Helene Barcelo, Woon-Puay Koh, Jian-Min Yuan
Affiliations

Mitochondrial DNA copy number is associated with breast cancer risk

Bharat Thyagarajan et al. PLoS One. .

Abstract

Mitochondrial DNA (mtDNA) copy number in peripheral blood is associated with increased risk of several cancers. However, data from prospective studies on mtDNA copy number and breast cancer risk are lacking. We evaluated the association between mtDNA copy number in peripheral blood and breast cancer risk in a nested case-control study of 183 breast cancer cases with pre-diagnostic blood samples and 529 individually matched controls among participants of the Singapore Chinese Health Study. The mtDNA copy number was measured using real time PCR. Conditional logistic regression analyses showed that there was an overall positive association between mtDNA copy number and breast cancer risk (P(trend) = 0.01). The elevated risk for higher mtDNA copy numbers was primarily seen for women with <3 years between blood draw and cancer diagnosis; ORs (95% CIs) for 2(nd), 3(rd), 4(th), and 5(th) quintile of mtDNA copy number were 1.52 (0.61, 3.82), 2.52 (1.03, 6.12), 3.12 (1.31, 7.43), and 3.06 (1.25, 7.47), respectively, compared with the 1(st) quintile (P(trend) = 0.004). There was no association between mtDNA copy number and breast cancer risk among women who donated a blood sample ≥3 years before breast cancer diagnosis (P(trend) = 0.41). This study supports a prospective association between increased mtDNA copy number and breast cancer risk that is dependent on the time interval between blood collection and breast cancer diagnosis. Future studies are warranted to confirm these findings and to elucidate the biological role of mtDNA copy number in breast cancer risk.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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