Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Sep 12:2013:930164.
doi: 10.1155/2013/930164.

Skin photoaging and the role of antioxidants in its prevention

Ruža Pandel  1 , Borut Poljšak, Aleksandar Godic, Raja Dahmane
Affiliations
Review

Skin photoaging and the role of antioxidants in its prevention

Ruža Pandel et al. ISRN Dermatol. .

Abstract

Photoaging of the skin depends primarily on the degree of ultraviolet radiation (UVR) and on an amount of melanin in the skin (skin phototype). In addition to direct or indirect DNA damage, UVR activates cell surface receptors of keratinocytes and fibroblasts in the skin, which leads to a breakdown of collagen in the extracellular matrix and a shutdown of new collagen synthesis. It is hypothesized that dermal collagen breakdown is followed by imperfect repair that yields a deficit in the structural integrity of the skin, formation of a solar scar, and ultimately clinically visible skin atrophy and wrinkles. Many studies confirmed that acute exposure of human skin to UVR leads to oxidation of cellular biomolecules that could be prevented by prior antioxidant treatment and to depletion of endogenous antioxidants. Skin has a network of all major endogenous enzymatic and nonenzymatic protective antioxidants, but their role in protecting cells against oxidative damage generated by UV radiation has not been elucidated. It seems that skin's antioxidative defence is also influenced by vitamins and nutritive factors and that combination of different antioxidants simultaneously provides synergistic effect.

PubMed Disclaimer

Figures

Figure 1
Figure 1
DermaView skin analyser accentuates areas of sun-damaged skin of the face.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Fisher GJ, Kang S, Varani J, et al. Mechanisms of photoaging and chronological skin aging. Archives of Dermatology. 2002;138(11):1462–1470. - PubMed
    1. Kligman LH, Kligman AM. The nature of photoaging: its prevention and repair. Photodermatology. 1986;3(4):215–227. - PubMed
    1. Yaar M, Eller MS, Gilchrest BA. Fifty years of skin aging. Journal of Investigative Dermatology Symposium Proceedings. 2002;7(1):51–58. - PubMed
    1. Gilchrest BA. Skin aging and photoaging. Dermatology Nursing. 1990;2(2):79–82. - PubMed
    1. Helfrich YR, Sachs DL, Voorhees JJ. Overview of skin aging and photoaging. Dermatology Nursing. 2008;20(3):177–184. - PubMed
-