Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal
- PMID: 24999379
- PMCID: PMC4066722
- DOI: 10.1155/2014/360438
Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal
Abstract
Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs). Over the last four decades, an extensive body of literature regarding lipid peroxidation has shown its important role in cell biology and human health. Since the early 1970s, the total published research articles on the topic of lipid peroxidation was 98 (1970-1974) and has been increasing at almost 135-fold, by up to 13165 in last 4 years (2010-2013). New discoveries about the involvement in cellular physiology and pathology, as well as the control of lipid peroxidation, continue to emerge every day. Given the enormity of this field, this review focuses on biochemical concepts of lipid peroxidation, production, metabolism, and signaling mechanisms of two main omega-6 fatty acids lipid peroxidation products: malondialdehyde (MDA) and, in particular, 4-hydroxy-2-nonenal (4-HNE), summarizing not only its physiological and protective function as signaling molecule stimulating gene expression and cell survival, but also its cytotoxic role inhibiting gene expression and promoting cell death. Finally, overviews of in vivo mammalian model systems used to study the lipid peroxidation process, and common pathological processes linked to MDA and 4-HNE are shown.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4066722/bin/OMCL2014-360438.001.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4066722/bin/OMCL2014-360438.002.gif)
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4066722/bin/OMCL2014-360438.003.gif)
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4066722/bin/OMCL2014-360438.004.gif)
![Figure 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4066722/bin/OMCL2014-360438.005.gif)
![Figure 6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4066722/bin/OMCL2014-360438.006.gif)
![Figure 7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4066722/bin/OMCL2014-360438.007.gif)
Similar articles
-
Contribution of the HNE-immunohistochemistry to modern pathological concepts of major human diseases.Free Radic Biol Med. 2017 Oct;111:110-126. doi: 10.1016/j.freeradbiomed.2016.12.009. Epub 2016 Dec 18. Free Radic Biol Med. 2017. PMID: 27993730 Review.
-
Hormetic and regulatory effects of lipid peroxidation mediators in pancreatic beta cells.Mol Aspects Med. 2016 Jun;49:49-77. doi: 10.1016/j.mam.2016.03.001. Epub 2016 Mar 21. Mol Aspects Med. 2016. PMID: 27012748 Review.
-
Formation of malondialdehyde (MDA), 4-hydroxy-2-hexenal (HHE) and 4-hydroxy-2-nonenal (HNE) in fish and fish oil during dynamic gastrointestinal in vitro digestion.Food Funct. 2016 Feb;7(2):1176-87. doi: 10.1039/c5fo01401h. Food Funct. 2016. PMID: 26824872
-
U-101033E (2,4-diaminopyrrolopyrimidine), a potent inhibitor of membrane lipid peroxidation as assessed by the production of 4-hydroxynonenal, malondialdehyde, and 4-hydroxynonenal--protein adducts.Biochem Pharmacol. 1998 Nov 15;56(10):1371-9. doi: 10.1016/s0006-2952(98)00266-4. Biochem Pharmacol. 1998. PMID: 9825737
-
Prooxidant-initiated lipid peroxidation in isolated rat hepatocytes: detection of 4-hydroxynonenal- and malondialdehyde-protein adducts.Chem Res Toxicol. 1997 Aug;10(8):895-905. doi: 10.1021/tx960181b. Chem Res Toxicol. 1997. PMID: 9282839
Cited by
-
Cell-cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calcium.Arch Toxicol. 2024 May 30. doi: 10.1007/s00204-024-03792-5. Online ahead of print. Arch Toxicol. 2024. PMID: 38814333
-
Pharmacodynamic Evaluation and Mechanism of Ginseng Polysaccharide against Nephrotoxicity Induced by Hexavalent Chromium.Nutrients. 2024 May 8;16(10):1416. doi: 10.3390/nu16101416. Nutrients. 2024. PMID: 38794654 Free PMC article.
-
Positive In Vitro Effect of ROCK Pathway Inhibitor Y-27632 on Qualitative Characteristics of Goat Sperm Stored at Low Temperatures.Animals (Basel). 2024 May 12;14(10):1441. doi: 10.3390/ani14101441. Animals (Basel). 2024. PMID: 38791659 Free PMC article.
-
Saliva as a Diagnostic Tool for Early Detection of Exercise-Induced Oxidative Damage in Female Athletes.Biomedicines. 2024 May 2;12(5):1006. doi: 10.3390/biomedicines12051006. Biomedicines. 2024. PMID: 38790968 Free PMC article.
-
The Antioxidant Dendrobium officinale Polysaccharide Modulates Host Metabolism and Gut Microbiota to Alleviate High-Fat Diet-Induced Atherosclerosis in ApoE-/- Mice.Antioxidants (Basel). 2024 May 13;13(5):599. doi: 10.3390/antiox13050599. Antioxidants (Basel). 2024. PMID: 38790704 Free PMC article.
References
-
- Frühbeck G, Gómez-Ambrosi J, Muruzábal FJ, Burrell MA. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. The American Journal of Physiology: Endocrinology and Metabolism. 2001;280(6):E827–E847. - PubMed
-
- Frayn KN. Regulation of fatty acid delivery in vivo. Advances in Experimental Medicine and Biology. 1998;441:171–179. - PubMed
-
- Vance E, Vance JE. Biochemistry: Biochemistry of Lipids, Lipoproteins and Membranes. 4th edition 2002.
-
- Massey KA, Nicolaou A. Lipidomics of polyunsaturated-fatty-acid-derived oxygenated metabolites. Biochemical Society Transactions. 2011;39(5):1240–1246. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources