Regulatory role of transcription factor SutR (YdcN) in sulfur utilization in Escherichia coli
- PMID: 25406449
- DOI: 10.1099/mic.0.083550-0
Regulatory role of transcription factor SutR (YdcN) in sulfur utilization in Escherichia coli
Abstract
Sulfur makes up 1 % of the dry mass of bacteria, and it is an abundant element (0.1 %) on earth. Sulfur in the environment is, however, mostly in oxidized forms and inaccessible to living organisms. At present, the entire assimilation pathway of external sulfur to sulfur-containing biomolecules and its regulation in Escherichia coli remain poorly understood, except for the metabolic pathway of cysteine synthesis, the first-step metabolite of sulfur assembly. During the search for regulation targets of uncharacterized transcription factors by Genomic SELEX screening, we found that the hitherto uncharacterized YdcN regulates a set of genes involved in the utilization of sulfur, including the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. Taking these findings together, we propose renaming YdcN as SutR (regulator of sulfur utilization).
© 2015 The Authors.
Similar articles
-
Transcription profile of Escherichia coli: genomic SELEX search for regulatory targets of transcription factors.Nucleic Acids Res. 2016 Mar 18;44(5):2058-74. doi: 10.1093/nar/gkw051. Epub 2016 Feb 3. Nucleic Acids Res. 2016. PMID: 26843427 Free PMC article.
-
Genomic SELEX Screening of Regulatory Targets of Escherichia coli Transcription Factors.Methods Mol Biol. 2018;1837:49-69. doi: 10.1007/978-1-4939-8675-0_4. Methods Mol Biol. 2018. PMID: 30109605
-
Transcription factor DecR (YbaO) controls detoxification of L-cysteine in Escherichia coli.Microbiology (Reading). 2016 Sep;162(9):1698-1707. doi: 10.1099/mic.0.000337. Epub 2016 Jul 19. Microbiology (Reading). 2016. PMID: 27435271
-
Sulfonate-sulfur metabolism and its regulation in Escherichia coli.Arch Microbiol. 2001 Jul;176(1-2):1-8. doi: 10.1007/s002030100298. Arch Microbiol. 2001. PMID: 11479697 Review.
-
FNR and its role in oxygen-regulated gene expression in Escherichia coli.FEMS Microbiol Rev. 1990 Aug;6(4):399-428. doi: 10.1111/j.1574-6968.1990.tb04109.x. FEMS Microbiol Rev. 1990. PMID: 2248796 Review.
Cited by
-
Identification of acidic stress-responsive genes and acid tolerance engineering in Synechococcus elongatus PCC 7942.Appl Microbiol Biotechnol. 2024 Dec;108(1):115. doi: 10.1007/s00253-023-12984-5. Epub 2024 Jan 10. Appl Microbiol Biotechnol. 2024. PMID: 38204133 Free PMC article.
-
XRE transcription factors conserved in Caulobacter and φCbK modulate adhesin development and phage production.PLoS Genet. 2023 Nov 16;19(11):e1011048. doi: 10.1371/journal.pgen.1011048. eCollection 2023 Nov. PLoS Genet. 2023. PMID: 37972151 Free PMC article.
-
Implications of xenobiotic-response element(s) and aryl hydrocarbon receptor in health and diseases.Hum Cell. 2023 Sep;36(5):1638-1655. doi: 10.1007/s13577-023-00931-5. Epub 2023 Jun 17. Hum Cell. 2023. PMID: 37329424 Review.
-
Unraveling the functions of uncharacterized transcription factors in Escherichia coli using ChIP-exo.Nucleic Acids Res. 2021 Sep 27;49(17):9696-9710. doi: 10.1093/nar/gkab735. Nucleic Acids Res. 2021. PMID: 34428301 Free PMC article.
-
A unified resource for transcriptional regulation in Escherichia coli K-12 incorporating high-throughput-generated binding data into RegulonDB version 10.0.BMC Biol. 2018 Aug 16;16(1):91. doi: 10.1186/s12915-018-0555-y. BMC Biol. 2018. PMID: 30115066 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous
