The "hitchhiking effect" revisited
- PMID: 2612899
- PMCID: PMC1203897
- DOI: 10.1093/genetics/123.4.887
The "hitchhiking effect" revisited
Abstract
The number of selectively neutral polymorphic sites in a random sample of genes can be affected by ancestral selectively favored substitutions at linked loci. The degree to which this happens depends on when in the history of the sample the selected substitutions happen, the strength of selection and the amount of crossing over between the sampled locus and the loci at which the selected substitutions occur. This phenomenon is commonly called hitchhiking. Using the coalescent process for a random sample of genes from a selectively neutral locus that is linked to a locus at which selection is taking place, a stochastic, finite population model is developed that describes the steady state effect of hitchhiking on the distribution of the number of selectively neutral polymorphic sites in a random sample. A prediction of the model is that, in regions of low crossing over, strongly selected substitutions in the history of the sample can substantially reduce the number of polymorphic sites in a random sample of genes from that expected under a neutral model.
Similar articles
-
The hitchhiking effect on linkage disequilibrium between linked neutral loci.Genetics. 2006 Apr;172(4):2647-63. doi: 10.1534/genetics.105.050179. Epub 2006 Feb 1. Genetics. 2006. PMID: 16452153 Free PMC article.
-
The dynamics of interlocus associations in the three locus hitchhiking model. 1. The three-way linkage disequilibrium function.J Math Biol. 1986;23(3):285-304. doi: 10.1007/BF00275250. J Math Biol. 1986. PMID: 3458866
-
The effect of a selected locus on linked neutral loci.Genetics. 1977 Apr;85(4):753-88. doi: 10.1093/genetics/85.4.753. Genetics. 1977. PMID: 863244 Free PMC article.
-
Divergent selection and heterogeneous genomic divergence.Mol Ecol. 2009 Feb;18(3):375-402. doi: 10.1111/j.1365-294X.2008.03946.x. Epub 2008 Dec 29. Mol Ecol. 2009. PMID: 19143936 Review.
-
Adaptive hitchhiking effects on genome variability.Curr Opin Genet Dev. 2001 Dec;11(6):635-41. doi: 10.1016/s0959-437x(00)00246-x. Curr Opin Genet Dev. 2001. PMID: 11682306 Review.
Cited by
-
Linked Selection and Gene Density Shape Genome-Wide Patterns of Diversification in Peatmosses.Evol Appl. 2024 Aug 19;17(8):e13767. doi: 10.1111/eva.13767. eCollection 2024 Aug. Evol Appl. 2024. PMID: 39165607 Free PMC article.
-
Signatures of selective sweeps in continuous-space populations.bioRxiv [Preprint]. 2024 Jul 26:2024.07.26.605365. doi: 10.1101/2024.07.26.605365. bioRxiv. 2024. PMID: 39091822 Free PMC article. Preprint.
-
Detection of selective sweep in European wild sheep breeds.3 Biotech. 2024 Apr;14(4):122. doi: 10.1007/s13205-024-03964-1. Epub 2024 Mar 28. 3 Biotech. 2024. PMID: 38560387
-
A quantitative genetic model of background selection in humans.PLoS Genet. 2024 Mar 20;20(3):e1011144. doi: 10.1371/journal.pgen.1011144. eCollection 2024 Mar. PLoS Genet. 2024. PMID: 38507461 Free PMC article.
-
Background Selection From Unlinked Sites Causes Nonindependent Evolution of Deleterious Mutations.Genome Biol Evol. 2024 Mar 2;16(3):evae050. doi: 10.1093/gbe/evae050. Genome Biol Evol. 2024. PMID: 38482769 Free PMC article.
References
MeSH terms
LinkOut - more resources
Full Text Sources