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. 2017 Apr:169:13-22.
doi: 10.1016/j.jinorgbio.2017.01.002. Epub 2017 Jan 4.

Delineating hierarchy of selenotranscriptome expression and their response to selenium status in chicken central nervous system

Xiu-Qing Jiang  1 , Chang-Yu Cao  1 , Zhao-Yang Li  1 , Wei Li  1 , Cong Zhang  1 , Jia Lin  1 , Xue-Nan Li  1 , Jing-Long Li  2
Affiliations

Delineating hierarchy of selenotranscriptome expression and their response to selenium status in chicken central nervous system

Xiu-Qing Jiang et al. J Inorg Biochem. 2017 Apr.

Abstract

Selenium (Se) incorporated in selenoproteins as selenocysteine and supports various important cellular and organismal functions. We recently reported that chicken brain exhibited high priority for Se supply and retention under conditions of dietary Se deficiency and supernutrition Li et al. (2012) . However, the selenotranscriptome expressions and their response to Se status in chicken central nervous system (CNS) are unclear. To better understand the relationship of Se homeostasis and selenoproteins expression in chicken CNS, 1day-old HyLine White chickens were fed a low Se diet (Se-L, 0.028mg/g) supplemented with 4 levels of dietary Se (0 to 5.0mgSe/kg) as Na2SeO3 for 8weeks. Then chickens were dissected for getting the CNS, which included cerebral cortex, cerebellum, thalamus, bulbus cinereus and marrow. The expressions of selenoproteome which have 24 selenoproteins were detected by the quantitative real-time PCR array. The concept of a selenoprotein hierarchy was developed and the hierarchy of different regions in chicken CNS was existence, especially cerebral cortex and bulbus cinereus. The expression of selenoproteins has a hierarch while changing Se content, and Selenoprotein T (Selt), Selenoprotein K (Selk), Selenoprotein W (Selw), Selenoprotein U (Selu), Glutathione peroxidase 3 (Gpx3), Glutathione peroxidase 4 (Gpx4), Selenoprotein P (Sepp1), Selenoprotein O (Selo), Selenoprotein 15 (Sel15), Selenoprotein N (Seln), Glutathione peroxidase 2 (Gpx2) and Selenoprotein P 2 (Sepp2) take more necessary function in the chicken CNS. Therefore, we hypothesize that hierarchy of regulated the transcriptions of selenoproteome makes an important role of CNS Se metabolism and transport in birds.

Keywords: Central nervous system; Chicken; Hierarchy; Selenium; Selenoproteome.

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