Epigenome-wide association studies for breast cancer risk and risk factors
- PMID: 28955137
- PMCID: PMC5612397
Epigenome-wide association studies for breast cancer risk and risk factors
Abstract
There have been six epigenome-wide association studies (EWAS) for breast cancer risk using blood DNA from prospective cohorts published thus far, and the only consistent finding is a global loss of methylation observed in breast cancer cases compared with controls, with no individual CpG sites passing validation across studies. In contrast, a more successful approach has been the identification of EWAS signatures of cancer risk factors such as smoking, body mass index, age and alcohol use with numerous validated CpG sites. These signatures may be used as a molecular test to quantify cancer risk associated with these factors. It is clear from the larger EWAS of risk exposures that similar-sized large collaborative studies may be needed to robustly identify DNA methylation signatures of breast cancer risk.
Keywords: DNA methylation; EWAS; breast cancer risk; epigenetics; epigenome-wide association study.
Conflict of interest statement
Conflict of Interest Statement The authors declare that they have no conflicts of interest.
Similar articles
-
Ten Years of EWAS.Adv Sci (Weinh). 2021 Oct;8(20):e2100727. doi: 10.1002/advs.202100727. Epub 2021 Aug 11. Adv Sci (Weinh). 2021. PMID: 34382344 Free PMC article. Review.
-
Linking Prenatal Environmental Exposures to Lifetime Health with Epigenome-Wide Association Studies: State-of-the-Science Review and Future Recommendations.Environ Health Perspect. 2023 Dec;131(12):126001. doi: 10.1289/EHP12956. Epub 2023 Dec 4. Environ Health Perspect. 2023. PMID: 38048101 Free PMC article. Review.
-
Epigenome-Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male Veterans.Alcohol Clin Exp Res. 2019 Oct;43(10):2111-2121. doi: 10.1111/acer.14168. Epub 2019 Aug 30. Alcohol Clin Exp Res. 2019. PMID: 31386212 Free PMC article.
-
DNA methylation in childhood asthma: an epigenome-wide meta-analysis.Lancet Respir Med. 2018 May;6(5):379-388. doi: 10.1016/S2213-2600(18)30052-3. Epub 2018 Feb 26. Lancet Respir Med. 2018. PMID: 29496485
-
Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis.Clin Epigenetics. 2015 Aug 4;7(1):67. doi: 10.1186/s13148-015-0104-2. eCollection 2015. Clin Epigenetics. 2015. PMID: 26244061 Free PMC article.
Cited by
-
A pilot study on DNA hypermethylation status in promoter region of P16 gene in patients with sporadic breast cancer.Med J Armed Forces India. 2022 Jul;78(3):322-326. doi: 10.1016/j.mjafi.2021.07.011. Epub 2021 Sep 30. Med J Armed Forces India. 2022. PMID: 35855710 Free PMC article.
-
Sparse principal component analysis based on genome network for correcting cell type heterogeneity in epigenome-wide association studies.Med Biol Eng Comput. 2022 Sep;60(9):2601-2618. doi: 10.1007/s11517-022-02599-9. Epub 2022 Jul 4. Med Biol Eng Comput. 2022. PMID: 35789457
-
Blood DNA methylation profiles improve breast cancer prediction.Mol Oncol. 2022 Jan;16(1):42-53. doi: 10.1002/1878-0261.13087. Epub 2021 Nov 9. Mol Oncol. 2022. PMID: 34411412 Free PMC article.
-
Ten Years of EWAS.Adv Sci (Weinh). 2021 Oct;8(20):e2100727. doi: 10.1002/advs.202100727. Epub 2021 Aug 11. Adv Sci (Weinh). 2021. PMID: 34382344 Free PMC article. Review.
-
Discovery of novel DNA methylation biomarkers for non-invasive sporadic breast cancer detection in the Latino population.Mol Oncol. 2021 Feb;15(2):473-486. doi: 10.1002/1878-0261.12842. Epub 2020 Nov 19. Mol Oncol. 2021. PMID: 33145876 Free PMC article.
References
Grants and funding
LinkOut - more resources
Full Text Sources