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. 2017 Sep 4;14(11):1110-1117.
doi: 10.7150/ijms.20547. eCollection 2017.

Effect of Coriolus versicolor Mycelia Extract on Exercise Performance and Physical Fatigue in Mice

Chun-Sheng Ho  1   2 , Yu-Tang Tung  3 , Woon-Man Kung  4 , Wen-Ching Huang  5 , Wing-Ki Leung  5 , Chi-Chang Huang  2   3 , Jyh-Horng Wu  6
Affiliations

Effect of Coriolus versicolor Mycelia Extract on Exercise Performance and Physical Fatigue in Mice

Chun-Sheng Ho et al. Int J Med Sci. .

Abstract

In this study, Coriolus versicolor mycelia (CVM) was evaluated the ergogenic and anti-fatigue activities. Male ICR mice were divided into four groups (n = 8/group) to receive vehicle or CVM by oral gavage for 4 weeks at 0, 615, 1230 or 3075 mg/kg/day, which were respectively designated the vehicle, CVM-1X, CVM-2X and CVM-5X groups. Forelimb grip strength, endurance swimming time, and levels of physical fatigue-associated parameters serum lactate, ammonia, glucose and creatine kinase (CK) after physical challenge were performed to evaluate exercise performance and anti-fatigue activity. Results revealed that the forelimb grip strength of mice in group CVM-1X, CVM-2X and CVM-5X were significantly increased by 1.20-, 1.18- and 1.23-fold, respectively, compared to the vehicle group. After the 15 minute swimming exercise, the levels of serum lactate of CVM-1X, CVM-2X and CVM-5X groups were significantly lower than the vehicle control group by 29%, 23% and 31%, respectively. The levels of ammonia in CVM-1X, CVM-2X and CVM-5X groups were significantly lowered by 22%, 25% and 41%, respectively, compared to the vehicle control group. In addition, the levels of serum CK in CVM-2X and CVM-5X groups were significantly lowered by 13% and 11%, respectively, compared to the vehicle control group. Accordingly, the supplementation with CVM has beneficial effects on performance improvement and anti-fatigue activity, and thus has great potential as a source for natural health products.

Keywords: Coriolus versicolor; anti-fatigue; exercise performance.; mycelia; polysaccharopeptide.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Effect of 4-week CVM on (A) forelimb grip strength and (B) endurance swimming performance in mice. Mice were pretreated with vehicle, CVM-1X, CVM-2X and CVM-5X for 28 days. Vehicle; vehicle control, CVM-1X; 615 mg/kg/day of CVM, CVM-2X; 1230 mg/kg/day of CVM, CVM-5X; 3075 mg/kg/day of CVM. Data are mean±SEM (n = 8 mice/group). Different letters (a, b) indicated significant difference at p<0.05 by one-way ANOVA.
Figure 2
Figure 2
Effect of 4-week CVM on (A) blood lactate, (B) blood ammonia, (C) creatine kinase (CK) and (D) glucose following a 15 min swim test. Mice were pretreated with vehicle, CVM-1X, CVM-2X and CVM-5X for 28 days. Vehicle; vehicle control, CVM-1X; 615 mg/kg/day of CVM, CVM-2X; 1230 mg/kg/day of CVM, CVM-5X; 3075 mg/kg/day of CVM. Data are mean±SEM (n = 8 mice/group). Different letters indicated significant difference at p<0.05 by one-way ANOVA.
Figure 3
Figure 3
Effect of 4-week CVM on pathological histology of liver, muscle, heat, kidney and lung tissues. Mice were pretreated with vehicle, CVM-1X, CVM-2X and CVM-5X for 28 days. Vehicle; vehicle control, CVM-1X; 615 mg/kg/day of CVM, CVM-2X; 1230 mg/kg/day of CVM, CVM-5X; 3075 mg/kg/day of CVM.
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