Advances in mRNA Vaccines for Infectious Diseases

doi:10.3389/fimmu.2019.00594

Review

. 2019 Mar 27:10:594.

doi: 10.3389/fimmu.2019.00594. eCollection 2019.

Advances in mRNA Vaccines for Infectious Diseases

Cuiling Zhang¹, Giulietta Maruggi², Hu Shan¹, Junwei Li¹

Affiliations

PMID: 30972078
PMCID: PMC6446947
DOI: 10.3389/fimmu.2019.00594

Review

Advances in mRNA Vaccines for Infectious Diseases

Cuiling Zhang et al. Front Immunol. 2019.

. 2019 Mar 27:10:594.

doi: 10.3389/fimmu.2019.00594. eCollection 2019.

Authors

Cuiling Zhang¹, Giulietta Maruggi², Hu Shan¹, Junwei Li¹

Affiliations

¹ College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
² GSK, Rockville, MD, United States.

PMID: 30972078
PMCID: PMC6446947
DOI: 10.3389/fimmu.2019.00594

Abstract

During the last two decades, there has been broad interest in RNA-based technologies for the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have shown that mRNA vaccines provide a safe and long-lasting immune response in animal models and humans. In this review, we summarize current research progress on mRNA vaccines, which have the potential to be quick-manufactured and to become powerful tools against infectious disease and we highlight the bright future of their design and applications.

Keywords: application; delivery; infectious disease; mRNA vaccine; mechanism.

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Figures

**Figure 1**
The mechanisms of different nucleic acid vaccines, including DNA vaccines, mRNA vaccines. MHC, Major histocompatibility complex.

See this image and copyright information in PMC

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References

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1. Li B, Fang L, Xu Z, Liu S, Gao J, Jiang Y, et al. . Recombination in vaccine and circulating strains of porcine reproductive and respiratory syndrome viruses. Emerg Infect Dis. (2009) 15:2032–5. 10.3201/eid1512.090390 - DOI - PMC - PubMed
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[1] Lents MP, Barbosa LP, Santana ALA, Pinheiro EEG, Mugabe LC, Biscarde CEA, et al. . Immunocastration of goats using anti-gonadotrophin releasing hormone vaccine. Theriogenology. (2018) 114:7–13. 10.1016/j.theriogenology.2018.03.013 - DOI - PubMed

[2] Lents MP, Barbosa LP, Santana ALA, Pinheiro EEG, Mugabe LC, Biscarde CEA, et al. . Immunocastration of goats using anti-gonadotrophin releasing hormone vaccine. Theriogenology. (2018) 114:7–13. 10.1016/j.theriogenology.2018.03.013 - DOI - PubMed

[3] Cuzick J. Preventive therapy for cancer. Lancet Oncol. (2017) 18:e472–e482. 10.1016/S1470-2045(17)30536-3 - DOI - PubMed

[4] Cuzick J. Preventive therapy for cancer. Lancet Oncol. (2017) 18:e472–e482. 10.1016/S1470-2045(17)30536-3 - DOI - PubMed

[5] Scheiblhofer S, Thalhamer J, Weiss R. DNA and mRNA vaccination against allergies. Pediatr Allergy Immunol. (2018) 29:679–88. 10.1111/pai.12964 - DOI - PMC - PubMed

[6] Scheiblhofer S, Thalhamer J, Weiss R. DNA and mRNA vaccination against allergies. Pediatr Allergy Immunol. (2018) 29:679–88. 10.1111/pai.12964 - DOI - PMC - PubMed

[7] Li B, Fang L, Xu Z, Liu S, Gao J, Jiang Y, et al. . Recombination in vaccine and circulating strains of porcine reproductive and respiratory syndrome viruses. Emerg Infect Dis. (2009) 15:2032–5. 10.3201/eid1512.090390 - DOI - PMC - PubMed

[8] Li B, Fang L, Xu Z, Liu S, Gao J, Jiang Y, et al. . Recombination in vaccine and circulating strains of porcine reproductive and respiratory syndrome viruses. Emerg Infect Dis. (2009) 15:2032–5. 10.3201/eid1512.090390 - DOI - PMC - PubMed

[9] Zhou B, Meliopoulos VA, Wang W, Lin X, Stucker KM, Halpin RA, et al. Wentworth. reversion of cold-adapted live attenuated influenza vaccine into a pathogenic virus. J Virol. (2016) 90:8454–63. 10.1128/JVI.00163-16 - DOI - PMC - PubMed

[10] Zhou B, Meliopoulos VA, Wang W, Lin X, Stucker KM, Halpin RA, et al. Wentworth. reversion of cold-adapted live attenuated influenza vaccine into a pathogenic virus. J Virol. (2016) 90:8454–63. 10.1128/JVI.00163-16 - DOI - PMC - PubMed

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Advances in mRNA Vaccines for Infectious Diseases

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Advances in mRNA Vaccines for Infectious Diseases

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