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Comparative Study
. 1986 Apr;5(4):823-6.
doi: 10.1002/j.1460-2075.1986.tb04288.x.

The relation between the divergence of sequence and structure in proteins

C Chothia, A M Lesk
Comparative Study

The relation between the divergence of sequence and structure in proteins

C Chothia et al. EMBO J. 1986 Apr.

Abstract

Homologous proteins have regions which retain the same general fold and regions where the folds differ. For pairs of distantly related proteins (residue identity approximately 20%), the regions with the same fold may comprise less than half of each molecule. The regions with the same general fold differ in structure by amounts that increase as the amino acid sequences diverge. The root mean square deviation in the positions of the main chain atoms, delta, is related to the fraction of mutated residues, H, by the expression: delta(A) = 0.40 e1.87H.

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