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. 1993 May;52(5):967-73.

Segregation analysis of fat mass and other body composition measures derived from underwater weighing

T Rice  1 , I B Borecki, C Bouchard, D C Rao
Affiliations

Segregation analysis of fat mass and other body composition measures derived from underwater weighing

T Rice et al. Am J Hum Genet. 1993 May.

Abstract

Segregation patterns of three body composition measures which were derived from underwater weighing were evaluated in a random sample of 176 French-Canadian families. Two of the variables can be considered as primary partitions of weight (fat mass [FM] and fat-free mass [FFM]), while the remaining variable (percent body fat [%BF]) is a derived index combining the measures of both fat and fat-free weight. This study represents the first report investigating major gene effects for these measures. Segregation analyses revealed that a major locus hypothesis could not be rejected for two of the three phenotypes. The single exception was FFM, for which nearly 60% of the variance was accounted for by a non-Mendelian major effect, which may reflect environmentally based commingling or may be in part a function of gene-environment interactions or correlations. In contrast to the results for FFM, the results for each of FM and %BF were similar and suggested a major locus which accounted for 45% of the variance, with an additional 22%-26% due to a multifactorial component. Given the similarity of the major gene characteristics for these two phenotypes, the possibility that the same gene underlies both measures warrants investigation. A reasonable hypothesis is to consider genes that may influence nutrient partitioning, as the family of candidate genes to receive the major attention.

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References

    1. Biometrics. 1976 Sep;32(3):695-9 - PubMed
    1. Int J Obes. 1991 Nov;15(11):763-73 - PubMed
    1. Hum Hered. 1981;31(5):312-21 - PubMed
    1. Am J Hum Genet. 1983 Sep;35(5):816-26 - PubMed
    1. Hum Biol. 1985 Feb;57(1):61-75 - PubMed

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