Oxidative stress, antioxidant status, and the contracting diaphragm
- PMID: 9494738
- DOI: 10.1139/h98-002
Oxidative stress, antioxidant status, and the contracting diaphragm
Abstract
Reactive oxygen species, including free radicals, are produced through a number of biochemical reactions, often as a consequence of aerobic metabolism. A system of antioxidant enzymes and scavenger substrates provides protection of membrane lipids, proteins, and DNA. An imbalance between production of reactive oxygen species and antioxidant protection results in "oxidative stress." Oxidative stress is believed to contribute to numerous pathological conditions including atherosclerosis, obstructive lung disease, aging, and fatigue of skeletal muscles including the diaphragm. Strenuous exercise, inflammation, infection, obstructive lung diseases, etc. increase exposure of the diaphragm to reactive oxygen species. Emerging data indicate that reactive oxygen species alter diaphragm contractions primarily in response to low-frequency stimulation. The response of the diaphragm is profoundly influenced by the degree of oxidative stress, fatigue state, glutathione status, and age. Exercise training results in an upregulation of antioxidant enzyme activities in the diaphragm and thus could provide additional protection against oxidative stress.
Similar articles
-
Effects of reactive oxygen species and interplay of antioxidants during physical exercise in skeletal muscles.J Physiol Biochem. 2018 Aug;74(3):359-367. doi: 10.1007/s13105-018-0633-1. Epub 2018 May 1. J Physiol Biochem. 2018. PMID: 29713940 Review.
-
Overexpression of antioxidant enzymes in diaphragm muscle does not alter contraction-induced fatigue or recovery.Exp Physiol. 2010 Jan;95(1):222-31. doi: 10.1113/expphysiol.2009.049650. Epub 2009 Sep 25. Exp Physiol. 2010. PMID: 19783618 Free PMC article.
-
Exercise at old age: does it increase or alleviate oxidative stress?Ann N Y Acad Sci. 2001 Apr;928:236-47. doi: 10.1111/j.1749-6632.2001.tb05653.x. Ann N Y Acad Sci. 2001. PMID: 11795515 Review.
-
Short-term exercise training improves diaphragm antioxidant capacity and endurance.Eur J Appl Physiol. 2000 Jan;81(1-2):67-74. doi: 10.1007/PL00013799. Eur J Appl Physiol. 2000. PMID: 10552269
-
Antioxidants and mitochondrial respiration in lung, diaphragm, and locomotor muscles: effect of exercise.Free Radic Biol Med. 1999 May;26(9-10):1292-9. doi: 10.1016/s0891-5849(98)00342-6. Free Radic Biol Med. 1999. PMID: 10381202
Cited by
-
Impact of Chlorogenic Acid on Peripheral Blood Mononuclear Cell Proliferation, Oxidative Stress, and Inflammatory Responses in Racehorses during Exercise.Antioxidants (Basel). 2023 Oct 28;12(11):1924. doi: 10.3390/antiox12111924. Antioxidants (Basel). 2023. PMID: 38001777 Free PMC article.
-
The Impact of Oxidative Stress on Pediatrics Syndromes.Antioxidants (Basel). 2022 Oct 5;11(10):1983. doi: 10.3390/antiox11101983. Antioxidants (Basel). 2022. PMID: 36290706 Free PMC article. Review.
-
Cardiopulmonary and Muscular Interactions: Potential Implications for Exercise (In)tolerance in Symptomatic Smokers Without Chronic Obstructive Pulmonary Disease.Front Physiol. 2019 Jul 10;10:859. doi: 10.3389/fphys.2019.00859. eCollection 2019. Front Physiol. 2019. PMID: 31354517 Free PMC article. Review.
-
The Effects of Swimming Training in Cold Water on Antioxidant Enzyme Activity and Lipid Peroxidation in Erythrocytes of Male and Female Aged Rats.Int J Environ Res Public Health. 2019 Feb 22;16(4):647. doi: 10.3390/ijerph16040647. Int J Environ Res Public Health. 2019. PMID: 30813224 Free PMC article.
-
Changes in Redox Signaling in the Skeletal Muscle with Aging.Oxid Med Cell Longev. 2019 Jan 17;2019:4617801. doi: 10.1155/2019/4617801. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 30800208 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical