Alternative titles; symbols
HGNC Approved Gene Symbol: AASDH
Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:56,338,290-56,387,491 (from NCBI)
Kasahara and Kato (2003) cloned mouse Aasdh (EC 1.2.1.31). The deduced 1,100-amino acid protein contains an N-terminal adenylation domain, followed by a thiolation domain and 7 tandem C-terminal binding sites for the redox cofactor pyrroloquinoline quinone (PQQ). Northern blot analysis detected Aasdh expression in all mouse tissues examined, with highest expression in heart, liver, and kidney.
By searching databases for sequences containing acyl-CoA synthetase motifs 1 and 2, Watkins et al. (2007) identified human AASDH, which they called ACSF4. The deduced 1,098-amino acid protein contains 4 of 5 motifs characteristic of acyl-CoA synthetases. Phylogenetic analysis revealed that ACSF4 belongs to a small group of acyl-CoA synthetases that differ significantly from all other clades of acyl-CoA synthetases and from each other.
Watkins et al. (2007) determined that the ACSF4 gene contains 15 exons.
Watkins et al. (2007) mapped the ACSF4 gene to the minus strand of chromosome 4q12.
Kasahara, T., Kato, T. A new redox-cofactor vitamin for mammals. Nature 422: 832 only, 2003. [PubMed: 12712191] [Full Text: https://doi.org/10.1038/422832a]
Watkins, P. A., Maiguel, D., Jia, Z., Pevsner, J. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. J. Lipid Res. 48: 2736-2750, 2007. [PubMed: 17762044] [Full Text: https://doi.org/10.1194/jlr.M700378-JLR200]