PANTHER Gene Information

Gene Symbol(s):

Ache

Organism:

Mus musculus

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Gene Name:

Acetylcholinesterase

Gene ID:

MGI:87876

Protein ID:

P21836

Persistent Id:

PTN000168476

Alternate Ids:

MGI:87876(MGI)	313754067(GI)
3.1.1.7(EC)	ACES_MOUSE(UniProtKB-ID)
CAA39867(EMBL-CDS)	ENSMUSG00000023328(Ensembl)
Ache(Symbol)	AF312033(EMBL)
CHEMBL3198(ChEMBL)	AChE(Synonym)
11423(GeneID)
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PANTHER Classification

PANTHER Family:	ACETYLCHOLINESTERASE (PTHR43918)
PANTHER Subfamily:	ACETYLCHOLINESTERASE (PTHR43918:SF11)
PANTHER GO-slim Molecular Function:	carboxylic ester hydrolase activity
PANTHER GO-slim Biological Process:	nitrogen compound metabolic process organic substance catabolic process
PANTHER GO-slim Cellular Component:	extracellular space plasma membrane
PANTHER protein class:	esterase

Pathway Categories:

Muscarinic acetylcholine receptor 2 and 4 signaling pathway

acetylcholinesterase

Nicotinic acetylcholine receptor signaling pathway

acetylcholinesterase

Muscarinic acetylcholine receptor 1 and 3 signaling pathway

acetylcholinesterase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	identical protein binding, protein binding, serine hydrolase activity, protein homodimerization activity, collagen binding, choline binding, acetylcholine binding, acetylcholinesterase activity, laminin binding, cholinesterase activity, carboxylic ester hydrolase activity, hydrolase activity
GO BP Complete:	acetylcholine metabolic process, acetylcholine catabolic process, retina development in camera-type eye, cell adhesion, synapse assembly, response to insulin, positive regulation of axonogenesis, acetylcholine receptor signaling pathway, choline metabolic process, positive regulation of cold-induced thermogenesis, receptor internalization, regulation of receptor recycling, positive regulation of dendrite morphogenesis
GO CC Complete:	presynaptic membrane, Golgi apparatus, neuronal cell body, synapse, extracellular region, plasma membrane, cell surface, nuclear envelope, endoplasmic reticulum lumen, dendrite, basement membrane, extracellular space, synaptic cleft, perinuclear region of cytoplasm, side of membrane, postsynaptic membrane, membrane, neuromuscular junction, axon

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
GORGO\|Ensembl=ENSGGOG00000001511.3\|UniProtKB=G3QGN3	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000058568.1\|UniProtKB=A0A5K1U1J8	Macaca mulatta	LDO
RAT\|RGD=69313\|UniProtKB=P37136	Rattus norvegicus	LDO
BOVIN\|Gene=ACHE\|UniProtKB=P23795	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000001139.6\|UniProtKB=F1MIM4	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000030303.4\|UniProtKB=I3LU85	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000006898.4\|UniProtKB=A0A3Q2H2J6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000023546\|UniProtKB=O62763	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845000697.1\|UniProtKB=A0A8I3MIG7	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000004882.4\|UniProtKB=A0A5F8GRV2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000050305.1\|UniProtKB=A0A6I8N2P3	Ornithorhynchus anatinus	LDO
CHICK\|Gene=ACHE\|UniProtKB=P36196	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010000453.1\|UniProtKB=A0A8V0X5B8	Gallus gallus	LDO
XENLA\|Gene=ache.L\|UniProtKB=B1WBB9	Xenopus laevis	O
XENLA\|Gene=ache.S\|UniProtKB=A0A8J0U398	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-923160\|UniProtKB=F7DYW2	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000010371.3\|UniProtKB=H2M3I8	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-010906-1\|UniProtKB=Q9DDE3	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000014072.1\|UniProtKB=W5N9N8	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000004635.3\|UniProtKB=B1H3L8	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118428688\|UniProtKB=A0A9J7N9G6	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423133\|UniProtKB=A0A9J7LRQ0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118429404\|UniProtKB=A0A9J7N9K1	Branchiostoma floridae	O
BRAFL\|Gene=LOC118406999\|UniProtKB=A0A9J7KAM7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118418088\|UniProtKB=A0A9J7LBL1	Branchiostoma floridae	O
BRAFL\|Gene=LOC118409683\|UniProtKB=A0A9J7KMK7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118427511\|UniProtKB=A0A9J7N804	Branchiostoma floridae	O
BRAFL\|Gene=LOC118426982\|UniProtKB=A0A9J7N766	Branchiostoma floridae	LDO
BRAFL\|Gene=LOC118423462\|UniProtKB=A0A9J7LR25	Branchiostoma floridae	O
BRAFL\|Gene=LOC118426981\|UniProtKB=A0A9J7M1A4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118429577\|UniProtKB=A0A9J7M768	Branchiostoma floridae	O
BRAFL\|Gene=LOC118428689\|UniProtKB=A0A9J7M510	Branchiostoma floridae	O
BRAFL\|Gene=LOC118408981\|UniProtKB=A0A9J7KL95	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC105436985\|UniProtKB=A0A7M7NLC9	Strongylocentrotus purpuratus	LDO
STRPU\|EnsemblGenome=LOC762935\|UniProtKB=A0A7M7GHM5	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00000035\|UniProtKB=P38433	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00036330\|UniProtKB=Q27459	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00105292\|UniProtKB=A0A2A6C715	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0000024\|UniProtKB=P07140	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP000466\|UniProtKB=Q7QFG0	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC000981\|UniProtKB=D6W9E2	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_44337\|UniProtKB=E9G1H3	Daphnia pulex	O
ANOGA\|EnsemblGenome=AGAP001356\|UniProtKB=Q869C3	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC014402\|UniProtKB=D6WLS4	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_39257\|UniProtKB=E9FRY6	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW012339\|UniProtKB=B7QCE8	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG120724\|UniProtKB=T1EGQ4	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG76935\|UniProtKB=T1G2R7	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG31933\|UniProtKB=B3SA29	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG19242\|UniProtKB=B3RKC5	Trichoplax adhaerens	O
EMENI\|EnsemblGenome=ANIA_10908\|UniProtKB=C8VD02	Emericella nidulans	O
NEUCR\|EnsemblGenome=NCU02679\|UniProtKB=Q7SH50	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_14441\|UniProtKB=A7FA10	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_01415\|UniProtKB=Q0V3J9	Phaeosphaeria nodorum	O
PHANO\|EnsemblGenome=SNOG_02525\|UniProtKB=Q0V0D9	Phaeosphaeria nodorum	O
USTMA\|EnsemblGenome=UMAG_11540\|UniProtKB=A0A0D1DYF7	Ustilago maydis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_27861\|UniProtKB=F4PCH6	Batrachochytrium dendrobatidis	O