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Martin T. Scott, Corynebacterium parvum as a Therapeutic Antitumor Agent in Mice. I. Systemic Effects From Intravenous Injection, JNCI: Journal of the National Cancer Institute, Volume 53, Issue 3, September 1974, Pages 855–860, https://doi.org/10.1093/jnci/53.3.855
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Summary
Two days after mastocytoma P815 was established as a solid tumor in the foot pads of (C57BL/6 × DBA/2)F1 mice, intravenous (iv) injection of Corynebacterium parvum caused only transient inhibition of tumor growth with no complete regressions. Tumor inhibition was reflected in increased survival times. Some toxicity problems were encountered after the high doses required for maximum effect were given, and multiple doses of C. parvum were no more effective than single doses. The antitumor effects of C. parvum were still apparent in T -celldeprived mice. Mice treated iv with C. parvum did not develop systemic antitumor immunity, but peritoneal macrophages and spleen cells from C. parvum-stimulated animals were nonspecifically cytostatic for mastocytoma cells in vitro. Thus systemic C. parvum was predominantly nonspecific in its mode of antitumor action.