Parent Class:

EC-Numbers → 3 -- Hydrolases → 3.8 -- Acting on halide bonds → 3.8.1 -- In C-halide compounds

Synonyms: AtzA

Systematic Name: atrazine chlorohydrolase

Unification Links: BRENDA:3.8.1.8, ENZYME:3.8.1.8, IUBMB-ExplorEnz:3.8.1.8

Reaction:
atrazine + H₂O → hydroxyatrazine + chloride + H⁺

Enzymes and Genes:
triazine hydrolase: trzN ( Nocardioides sp. C190 )
triazine hydrolase: trzN ( Paenarthrobacter aurescens TC1 )
atrazine chlorohydrolase: atzA ( Pseudomonas sp. ADP )

Summary:
Involved in the degradation of the herbicide atrazine, 2-chloro- 4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine, in bacteria.

Citations: [deSouza95, deSouza96]

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References

deSouza95: de Souza ML, Wackett LP, Boundy-Mills KL, Mandelbaum RT, Sadowsky MJ (1995). "Cloning, characterization, and expression of a gene region from Pseudomonas sp. strain ADP involved in the dechlorination of atrazine." Appl Environ Microbiol 1995;61(9);3373-8. PMID: 7574646

deSouza96: de Souza ML, Sadowsky MJ, Wackett LP (1996). "Atrazine chlorohydrolase from Pseudomonas sp. strain ADP: gene sequence, enzyme purification, and protein characterization." J Bacteriol 1996;178(16);4894-900. PMID: 8759853

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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