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High dose aspirin and left ventricular remodeling after myocardial infarction

Aspirin and myocardial infarction

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Basic Research in Cardiology Aims and scope Submit manuscript

Abstract

Background

Proinflammatory proteins like inflammatory cytokines are implicated in myocardial depression and left ventricular remodeling after myocardial infarction. High-dose aspirin inhibits cytokine activation. Therefore, we tested the influence of high-dose aspirin treatment on left ventricular remodeling in mice after myocardial infarction.

Methods and results

Mice were treated for 4 weeks with placebo or aspirin (120 mg/kg per day) by Alzet mini-osmotic pumps after ligation of the left anterior descending coronary artery. Serial transthoracic echocardiography was performed at days 1, 7, and 28. Over the 4 weeks, mortality was not different between the groups (placebo 30.8%, aspirin 30.8%). On echocardiography, animals after myocardial infarction exhibited left ventricular dilatation (week 4, end-systolic area, placebo sham 8.9 ± 1.7 vs. placebo MI 15.9 ± 2.5 mm2), which was not changed by aspirin treatment (week 4, end-systolic area, aspirin MI 14.5 ± 1.3 mm2, p= ns vs. placebo MI). The expression of the proinflammatory cytokines TNF and IL-1β were markedly upregulated in mice with myocardial infarction on placebo. Cytokine expression was significantly reduced by aspirin treatment while collagen deposition was not influenced.

Conclusion

Continuous aspirin treatment (120 mg/kg/d) reduces the expression of proinflammatory cytokines after myocardial infarction, but does not affect post-infarct cardiac remodeling and cardiac function.

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik I der Universität Würzburg, Josef Schneider-Straße 2, 97080, Würzburg, Germany

    A. Adamek, K. Hu MD, B. Bayer, H. Wagner, G. Ertl MD, J. Bauersachs MD & Stefan Frantz MD

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  1. A. Adamek
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  2. K. Hu MD
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  3. B. Bayer
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  4. H. Wagner
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  5. G. Ertl MD
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  6. J. Bauersachs MD
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  7. Stefan Frantz MD
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Correspondence to Stefan Frantz MD.

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Adamek, A., Hu, K., Bayer, B. et al. High dose aspirin and left ventricular remodeling after myocardial infarction. Basic Res Cardiol 102, 334–340 (2007). https://doi.org/10.1007/s00395-007-0647-2

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  • DOI: https://doi.org/10.1007/s00395-007-0647-2

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