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Immunologic Aspects of Human Colostrum and Milk: Interaction with the Intestinal Immunity of the Neonate

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Secretory Immunity and Infection

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 107))

Abstract

Human colostrum and milk contains T and B lymphocytes, macrophages and the major classes of immunoglobulins (1). The bulk of the immunoglobulins in colostrum and milk belong to the secretory (11S) IgA class (2,3). It has been suggested that the secretory IgA antibody activity found in the mammary glands and in colostrum is largely derived from the gut associated lymphoid tissue (4). Little or no information is available regarding the distribution of antibody producing cells and the levels of immunoglobulins in colostrum and milk at various times after onset of lactation. Fragmentary data are available on T-lymphocyte function and in vitro correlates of cell-mediated immunity in colostrum and milk (1,4). Little is known about the intestinal absorption of the immunoglobulins and cellular components in colostrum.

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Author information

Authors and Affiliations

  1. Departments of Pediatrics, Microbiology and Obstetrics and Gynecology, School of Medicine, State University of New York at Buffalo, 219 Bryant Street, Buffalo, New York, USA

    S. S. Ogra, D. I. Weintraub & P. L. Ogra

  2. Division of Infectious Disease and Virology, Children’s Hospital, 219 Bryant Street, Buffalo, New York, USA

    S. S. Ogra, D. I. Weintraub & P. L. Ogra

Authors
  1. S. S. Ogra
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  2. D. I. Weintraub
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  3. P. L. Ogra
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Editor information

Editors and Affiliations

  1. Institute of Dental Research, Departments of Microbiology and Medicine, Comprehesive Cancer Center, University of Alabama in Birmingham, Birmingham, Alabama, USA

    Jerry R. McGhee , Jiri Mestecky  & James L. Babb ,  & 

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© 1978 Plenum Press, New York

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Ogra, S.S., Weintraub, D.I., Ogra, P.L. (1978). Immunologic Aspects of Human Colostrum and Milk: Interaction with the Intestinal Immunity of the Neonate. In: McGhee, J.R., Mestecky, J., Babb, J.L. (eds) Secretory Immunity and Infection. Advances in Experimental Medicine and Biology, vol 107. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3369-2_12

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  • DOI: https://doi.org/10.1007/978-1-4684-3369-2_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3371-5

  • Online ISBN: 978-1-4684-3369-2

  • eBook Packages: Springer Book Archive

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