Skip to main content
SpringerLink
Log in

Mouse Models that Target Individual Selenoproteins

  • Chapter
  • First Online:
Selenium

Abstract

Selenium deficiency in humans or livestock and impaired selenoprotein synthesis in patients due to mutations in relevant genes have revealed the importance of selenoproteins for healthy life. Twenty-four genes for selenoproteins are encoded in the murine genome, and most of them have been genetically inactivated. We summarize the results from those studies that have provided a series of intriguing mechanistic details about the importance of selenoprotein-dependent processes for proper neuronal, retinal, cardiac, endothelial, and renal function as well as the contribution of selenoprotein activity to the endocrine, immune and gastrointestinal systems, and reproduction. Mouse models were particularly useful for the study of organs that are not easily accessible for biopsy in humans. While four selenoproteins have proven to be crucial for murine embryo and tissue development, others confer more specific functions particularly in response to stress.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (Canada)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (Canada)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (Canada)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (Canada)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

') var buybox = document.querySelector("[data-id=id_"+ timestamp +"]").parentNode var buyingOptions = buybox.querySelectorAll(".buying-option") ;[].slice.call(buyingOptions).forEach(initCollapsibles) var buyboxMaxSingleColumnWidth = 480 function initCollapsibles(subscription, index) { var toggle = subscription.querySelector(".buying-option-price") subscription.classList.remove("expanded") var form = subscription.querySelector(".buying-option-form") var priceInfo = subscription.querySelector(".price-info") var buyingOption = toggle.parentElement if (toggle && form && priceInfo) { toggle.setAttribute("role", "button") toggle.setAttribute("tabindex", "0") toggle.addEventListener("click", function (event) { var expandedBuyingOptions = buybox.querySelectorAll(".buying-option.expanded") var buyboxWidth = buybox.offsetWidth ;[].slice.call(expandedBuyingOptions).forEach(function(option) { if (buyboxWidth <= buyboxMaxSingleColumnWidth && option != buyingOption) { hideBuyingOption(option) } }) var expanded = toggle.getAttribute("aria-expanded") === "true" || false toggle.setAttribute("aria-expanded", !expanded) form.hidden = expanded if (!expanded) { buyingOption.classList.add("expanded") } else { buyingOption.classList.remove("expanded") } priceInfo.hidden = expanded }, false) } } function hideBuyingOption(buyingOption) { var toggle = buyingOption.querySelector(".buying-option-price") var form = buyingOption.querySelector(".buying-option-form") var priceInfo = buyingOption.querySelector(".price-info") toggle.setAttribute("aria-expanded", false) form.hidden = true buyingOption.classList.remove("expanded") priceInfo.hidden = true } function initKeyControls() { document.addEventListener("keydown", function (event) { if (document.activeElement.classList.contains("buying-option-price") && (event.code === "Space" || event.code === "Enter")) { if (document.activeElement) { event.preventDefault() document.activeElement.click() } } }, false) } function initialStateOpen() { var buyboxWidth = buybox.offsetWidth ;[].slice.call(buybox.querySelectorAll(".buying-option")).forEach(function (option, index) { var toggle = option.querySelector(".buying-option-price") var form = option.querySelector(".buying-option-form") var priceInfo = option.querySelector(".price-info") if (buyboxWidth > buyboxMaxSingleColumnWidth) { toggle.click() } else { if (index === 0) { toggle.click() } else { toggle.setAttribute("aria-expanded", "false") form.hidden = "hidden" priceInfo.hidden = "hidden" } } }) } initialStateOpen() if (window.buyboxInitialised) return window.buyboxInitialised = true initKeyControls() })()

Institutional subscriptions

Similar content being viewed by others

References

  1. EA Cerwenka Jr, WC Cooper 1961 Arch Environ Health 3:189

    Article  CAS  PubMed  Google Scholar 

  2. GV Kryukov et al 2003 Science 300:1439

    Article  CAS  PubMed  Google Scholar 

  3. K Ge et al 1983 Virchows Arch A Pathol Anat Histopathol 401:1

    Article  CAS  PubMed  Google Scholar 

  4. R Moreno-Reyes et al 1998 N Engl J Med 339:1112

    Article  CAS  PubMed  Google Scholar 

  5. AM Dumitrescu et al 2005 Nat Genet 37:1247

    Article  CAS  PubMed  Google Scholar 

  6. E Schoenmakers et al 2010 J Clin Invest 120:4220

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. MR Bosl et al 1997 Proc Natl Acad Sci U S A 94:5531

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. M Conrad 2009 Biochim Biophys Acta 1790:1575

    Article  CAS  PubMed  Google Scholar 

  9. MT Castex et al 2015 Mol Neurobiol doi:10.1007/s12035-015-9505-7

    Google Scholar 

  10. S Seeher et al 2014 Antioxid Redox Signal 21:835

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. S Seeher et al 2014 Biochem J 462:67

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. EK Wirth et al 2010 FASEB J 24:844

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. L Schomburg, U Schweizer 2009 Biochim Biophys Acta 1790:1453

    Article  CAS  PubMed  Google Scholar 

  14. KE Hill et al 2003 J Biol Chem 278:13640

    Article  CAS  PubMed  Google Scholar 

  15. L Schomburg et al 2003 Biochem J 370:397

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. KE Hill et al 2012 J Biol Chem 287:40414

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. U Schweizer et al 2005 Biochem J 386:221

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. K Renko et al 2008 Biochem J 409:741

    Article  CAS  PubMed  Google Scholar 

  19. LA Seale et al 2012 Mol Cell Biol 32:4141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Y Mahdi et al 2015 PLoS One 10:e0127349

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  21. R Brigelius-Flohe, M Maiorino 2013 Biochim Biophys Acta 1830:3289

    Article  CAS  PubMed  Google Scholar 

  22. JT Rotruck et al 1973 Science 179:588

    Article  CAS  PubMed  Google Scholar 

  23. L Flohe et al 1973 FEBS Lett 32:132

    Article  CAS  PubMed  Google Scholar 

  24. YS Ho et al 1997 J Biol Chem 272:16644

    Article  CAS  PubMed  Google Scholar 

  25. M Conrad, U Schweizer 2010 Antioxid Redox Signal 12:851

    Article  CAS  PubMed  Google Scholar 

  26. CC Lim et al 2009 Am J Physiol Heart Circ Physiol 297:H2144

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. PJ Crack et al 2001 J Neurochem 78:1389

    Article  CAS  PubMed  Google Scholar 

  28. Y Fu et al 1999 Free Radic Biol Med 27:605

    Article  CAS  PubMed  Google Scholar 

  29. KK Ohlemiller et al 2000 J Assoc Res Otolaryngol 1:243

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. MA Beck et al 1998 FASEB J 12:1143

    CAS  PubMed  Google Scholar 

  31. P Klivenyi et al 2000 J Neurosci 20:1

    CAS  PubMed  Google Scholar 

  32. RS Esworthy et al 2000 Am J Physiol Gastrointest Liver Physiol 279:G426

    CAS  PubMed  Google Scholar 

  33. MA Forgione et al 2002 Am J Physiol Heart Circ Physiol 282:H1255

    Article  CAS  PubMed  Google Scholar 

  34. J Walshe et al 2007 Cancer Res 67:4751

    Article  CAS  PubMed  Google Scholar 

  35. J Gao et al 2008 Biochim Biophys Acta 1783:2020

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. K Loh et al 2009 Cell Metab 10:260

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. RS Esworthy et al 2001 Am J Physiol Gastrointest Liver Physiol 281:G848

    CAS  PubMed  Google Scholar 

  38. S Florian et al 2010 Free Radic Biol Med 49:1694

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. S Krehl et al 2012 Carcinogenesis 33:620

    Article  CAS  PubMed  Google Scholar 

  40. MF Muller et al 2013 PLoS One 8:e72055

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  41. AM Dittrich et al 2010 Eur Respir J 35:1148

    Article  CAS  PubMed  Google Scholar 

  42. GE Olson et al 2010 Am J Physiol Renal Physiol 298:F1244

    Article  CAS  PubMed  Google Scholar 

  43. RC Jin et al 2011 Circulation 123:1963

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. B Voetsch et al 2007 Stroke 38:41

    Article  CAS  PubMed  Google Scholar 

  45. CW Barrett et al 2013 Cancer Res 73:1245

    Article  CAS  PubMed  Google Scholar 

  46. F Ursini et al 1985 Biochim Biophys Acta 839:62

    Article  CAS  PubMed  Google Scholar 

  47. LJ Yant et al 2003 Free Radic Biol Med 34:496

    Article  CAS  PubMed  Google Scholar 

  48. A Seiler et al 2008 Cell Metab 8:237

    Article  CAS  PubMed  Google Scholar 

  49. M Conrad 2012 in Selenium: Its Molecular Biology and Role in Human Health, DL Hatfield et al Eds (Springer Science + Business Media, LLC, New York) p 547

    Google Scholar 

  50. M Conrad et al 2010 Proc Natl Acad Sci U S A 107:15774

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. WS Yang et al 2014 Cell 156:317

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. JP Friedmann Angeli et al 2014 Nat Cell Biol 16:1180

    Article  CAS  PubMed  Google Scholar 

  53. AC Smith et al 2014 J Med Genet 51:470

    Article  CAS  PubMed  Google Scholar 

  54. E Wallace et al 1983 Gamete Res. 4:377

    Article  Google Scholar 

  55. F Ursini et al 1999 Science 285:1393

    Article  CAS  PubMed  Google Scholar 

  56. M Schneider et al 2009 FASEB J 23:3233

    Article  CAS  PubMed  Google Scholar 

  57. H Liang et al 2009 J Biol Chem 284:30836

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. H Pfeifer et al 2001 FASEB J 15:1236

    Article  CAS  PubMed  Google Scholar 

  59. M Conrad et al 2005 Mol Cell Biol 25:7637

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. R Puglisi et al 2012 J Cell Physiol 227:1420

    Article  CAS  PubMed  Google Scholar 

  61. ES Arner 2009 Biochim Biophys Acta 1790:495

    Article  CAS  PubMed  Google Scholar 

  62. M Conrad et al 2004 Mol Cell Biol 24:9414

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. J Horstkotte et al 2011 Circulation 124:2892

    Article  CAS  PubMed  Google Scholar 

  64. C Kiermayer et al 2015 J Am Heart Assoc 4:e002153

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  65. D Sibbing et al 2011 Eur Heart J 32:1121

    Article  CAS  PubMed  Google Scholar 

  66. J Hellfritsch et al 2015 Antioxid Redox Signal 22:938

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. R Prasad et al 2014 J Clin Endocrinol Metab 99:E1556

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. C Jakupoglu et al 2005 Mol Cell Biol 25:1980

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. AA Bondareva et al 2007 Free Radic Biol Med 43:911

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. J Soerensen et al 2008 PLoS One 3:e1813

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  71. E Holzerova et al 2016 Brain 139:346

    Article  PubMed  Google Scholar 

  72. MF Rollins et al 2010 J Cell Sci 123:2402

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. BA Carlson et al 2012 Carcinogenesis 33:1806

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. AD Patterson et al 2013 Chem Res Toxicol 26:1088

    Article  CAS  PubMed  Google Scholar 

  75. SV Iverson et al 2013 Free Radic Biol Med 63:369

    Article  CAS  PubMed  Google Scholar 

  76. S Eriksson et al 2015 Nat Commun 6:6479

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. D Su et al 2005 J Biol Chem 280:26491

    Article  CAS  PubMed  Google Scholar 

  78. U Schweizer, C Steegborn 2015 J Mol Endocrinol 55:R37

    Article  CAS  PubMed  Google Scholar 

  79. LA de Jesus et al 2001 J Clin Invest 108:1379

    Article  PubMed  PubMed Central  Google Scholar 

  80. L Ng et al 2004 Proc Natl Acad Sci U S A 101:3474

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. MJ Schneider et al 2001 Mol Endocrinol 15:2137

    Article  CAS  PubMed  Google Scholar 

  82. JP Werneck de Castro et al 2015 J Clin Invest 125:769

    Article  PubMed  PubMed Central  Google Scholar 

  83. M Dentice et al 2010 J Clin Invest 120:4021

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. C Luongo et al 2015 Endocrinology 156:745

    Article  PubMed  CAS  Google Scholar 

  85. TL Fonseca et al 2013 J Clin Invest 123:1492

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. TL Fonseca et al 2014 Diabetes 63:1594

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. MJ Schneider et al 2006 Endocrinology 147:580

    Article  CAS  PubMed  Google Scholar 

  88. F Streckfuss et al 2005 Biochem Biophys Res Commun 337:739

    Article  CAS  PubMed  Google Scholar 

  89. VA Galton et al 2009 Endocrinology 150:2957

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. ME Martinez et al 2016 Endocrinology 157:1276

    Article  PubMed  Google Scholar 

  91. MC Medina et al 2014 Endocrinology 155:3160

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  92. RP Peeters et al 2013 Endocrinology 154:550

    Article  CAS  PubMed  Google Scholar 

  93. L Ng et al 2010 J Neurosci 30:3347

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. L Ng et al 2009 Endocrinology 150:1952

    Article  CAS  PubMed  Google Scholar 

  95. A Hernandez et al 2006 J Clin Invest 116:476

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. M Dentice et al 2014 Cell Metab 20:1038

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. MV Kasaikina et al 2011 J Biol Chem 286:33203

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. PA Tsuji et al 2012 PLoS One 7:e50574

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. S Verma et al 2011 J Immunol 186:2127

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. S Meiler et al 2013 J Leukoc Biol 93:771

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. GJ Fredericks et al 2014 Proc Natl Acad Sci U S A 111:16478

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. MW Pitts et al 2013 J Biol Chem 288:26121

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. B Moghadaszadeh et al 2001 Nat Genet 29:17

    Article  CAS  PubMed  Google Scholar 

  104. V Allamand et al 2006 EMBO Rep 7:450

    CAS  PubMed  PubMed Central  Google Scholar 

  105. B Maiti et al 2009 Hum Mutat 30:411

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  106. MT Howard et al 2005 EMBO J 24:1596

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. DE Fomenko et al 2009 J Biol Chem 284:5986

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  108. H Zhao et al 2012 Arch Biochem Biophys 522:37

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. BC Lee et al 2013 Mol Cell 51:397

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. L Grumolato et al 2008 FASEB J 22:1756

    Article  CAS  PubMed  Google Scholar 

  111. G Prevost et al 2013 Endocrinology 154:3796

    Article  CAS  PubMed  Google Scholar 

  112. E Kumaraswamy et al 2003 Mol Cell Biol 23:1477

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  113. AV Raman et al 2012 Genes Brain Behav 11:601

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  114. H Imai et al 2003 Biochem Biophys Res Commun 305:278

    Article  CAS  PubMed  Google Scholar 

  115. MR Garry et al 2008 Free Radic Biol Med 44:1075

    Article  CAS  PubMed  Google Scholar 

  116. M Rederstorff et al 2011 PLoS One 6:e23094

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  117. P Castets et al 2011 Hum Mol Genet 20:694

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We have tried to avoid too much overlap with other Chapters of this book and thus apologize to those, whose work could not be cited here for space restrictions. This work was supported by the Deutsche Forschungsgemeinschaft (DFG) grants CO 291/2-3 and CO 291/5-1 as well as the Human Frontier Science Program RGP0013/14 to M.C. U.S. received funding from DFG grants Schw914/2-2 and Schw914/6-1.

Author information

Authors and Affiliations

  1. Helmholtz Zentrum München, Institute of Developmental Genetics, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany

    Marcus Conrad

  2. Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Nussallee 11, 53115, Bonn, Germany

    Ulrich Schweizer

Authors
  1. Marcus Conrad
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ulrich Schweizer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ulrich Schweizer .

Editor information

Editors and Affiliations

  1. Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute, Bethesda, Maryland, USA

    Dolph L. Hatfield

  2. Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Nordrhein-Westfalen, Germany

    Ulrich Schweizer

  3. Department of Biological Sciences, Towson University, Towson, Maryland, USA

    Petra A. Tsuji

  4. Division of Genetics, Department of Medicine, Brigham and Women’s Hospital Harvard Medical School, Boston, Massachusetts, USA

    Vadim N. Gladyshev

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Conrad, M., Schweizer, U. (2016). Mouse Models that Target Individual Selenoproteins. In: Hatfield, D., Schweizer, U., Tsuji, P., Gladyshev, V. (eds) Selenium. Springer, Cham. https://doi.org/10.1007/978-3-319-41283-2_47

Download citation

Publish with us

Policies and ethics

Search

Navigation

-