Skip to main content

Advertisement

SpringerLink
Log in

Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease

  • Rapid communication
  • Published:
Human Genetics Aims and scope Submit manuscript

Abstract

Oxidative stress has been suggested to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer disease (AD) and Parkinson disease (PD). Heme oxygenase-1 (HO-1), a key enzyme in heme catabolism, also functions as an antioxidant enzyme. Here, we show that a (GT)n repeat in the human HO-1 gene promoter region is highly polymorphic, although no particular alleles are associated with AD or PD. This newly identified genetic marker should allow us to study the possible involvement of HO-1 in certain human diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Canada)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Neurology, Tohoku University School of Medicine, 1–1 Seiryomachi, Aobaku, Sendai 980-77, Japan Tel.: +81-22-717-7189; Fax: +81-22-717-7192 e-mail: atakeda@neurol.med.tohoku.ac.jp, , , , , , JP

    Teiko Kimpara, A. Takeda, Koichi Watanabe & Yasuto Itoyama

  2. Department of Molecular Genetics, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan, , , , , , JP

    Shuntaro Ikawa & Minro Watanabe

  3. Department of Geriatrics, Tohoku University School of Medicine, Sendai, Japan, , , , , , JP

    Hiroyuki Arai & Hidetada Sasaki

  4. Department of Psychiatry, National Institute on Alcoholism, Kurihama National Hospital, Kanagawa, Japan, , , , , , JP

    Susumu Higuchi

  5. Department of Neurology, Kohnan Hospital, Sendai, Japan, , , , , , JP

    Naoshi Okita & Sadao Takase

  6. Department of Neurology, National Nishitaga Hospital, Sendai, Japan, , , , , , JP

    Hiroshi Saito

  7. Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Sendai, Japan, , , , , , JP

    Kazuhiro Takahashi & Shigeki Shibahara

Authors
  1. Teiko Kimpara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Takeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Koichi Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yasuto Itoyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shuntaro Ikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Minro Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hiroyuki Arai
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hidetada Sasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Susumu Higuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Naoshi Okita
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Sadao Takase
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Hiroshi Saito
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Kazuhiro Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Shigeki Shibahara
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received: 5 November 1996 / Accepted: 18 February 1997

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kimpara, T., Takeda, A., Watanabe, K. et al. Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease. Hum Genet 100, 145–147 (1997). https://doi.org/10.1007/s004390050480

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004390050480

Keywords

Search

Navigation

-