Abstract
Introduction
Poor gestational outcomes due to placental insufficiency can have lifelong consequences for mother and child.
Objective
There is a need for better methods of diagnosis, and elemental metabolomics may provide a means to determine the risk of gestational disorders.
Methods
This study used blood plasma samples collected at 36 weeks’ gestation from women who later developed preeclampsia (n = 38), or small-for-gestational age babies (n = 91), along with matched controls (n = 193). Multi-element analysis was conducted by inductively coupled plasma mass spectrometer (ICP-MS), allowing simultaneous measurement of 28 elements.
Results
Women who later developed PE, exhibited significantly increased concentrations of K, Rb and Ba. For SGA pregnancies, there was a significant increase in Cu and a decrease in As concentrations. Despite significant differences in single elements, the elemental profile of groups indicated no clustering of control, PE, or SGA samples. Positive predicative values correctly identified approximately 60% of SGA and 70% of PE samples.
Conclusion
This is the first-time elemental metabolomics has been used to predict SGA and PE at 36 weeks. Though significant changes were identified, routine clinical use may be limited but may contribute to a multi marker test. Future analysis should include other biomarkers, metabolic data or clinical measurements made throughout gestation.
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Acknowledgements
The authors would like to acknowledge the financial support of the Norman Beisher Medical Research Foundation (NBMRF), and the Allen Foundation. The authors would also like to thank all the participants, and researchers who contributed to the Fetal Longitudinal Assessment of Growth cohort.
Funding
This research was funded by the Norman Beisher Medical Research Foundation (NBMRF), and the Allen Foundation.
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Conceptualization, DRM, JJF, TM, SW, ST, WWB, TJK-L, and AVP; methodology, DRM, TM, SW, ST, WWB, and TJK-L; formal analysis, DRM; data curation, TM; writing—original draft preparation, DRM; writing—review and editing, JJF, ST, TJK-L, and AVP; supervision, TJK-L, and AVP; project administration, TM, SW, ST, TJK-L, and AVP; funding acquisition, TJK-L, and AVP. All authors have read and agreed to the published version of the manuscript.” Please turn to the CRediT taxonomy for the term explanation. Authorship must be limited to those who have contributed substantially to the work reported.
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FLAG study ran from 2015 through to 2016 and was approved by the Mercy Health Research Ethics Committee, Ethics Approval Number R14/12.
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McKeating, D.R., Fisher, J.J., MacDonald, T. et al. Circulating trace elements for the prediction of preeclampsia and small for gestational age babies. Metabolomics 17, 90 (2021). https://doi.org/10.1007/s11306-021-01840-0
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DOI: https://doi.org/10.1007/s11306-021-01840-0