Abstract
This present study was undertaken to investigate whether arsenic exposure increases the risk of children’s low intelligence quotient (IQ) in China. MEDLINE, SCI, CNKI, and CBM search were organized for all documents published, in English and Chinese, between 1988 and 2008 using the following keywords: arsenic, intelligence, and IQ. As a result, four cross-sectional studies that assessed the development of low IQ in children who had been exposed to arsenic earlier in their life were included in this study. The summary weighted mean difference of IQ was calculated in this meta-analyses, when arsenicosis areas or slight arsenicosis areas were compared with non-arsenicosis areas; it is −6.85 (95% confidence interval [CI] = −8.30 to −5.41; p < 0.01, using a fixed effect model) and −6.54 (95%CI = −8.93 to −4.15; p < 0.01, using a random effect model), which means that children who live in an arsenicosis area or a slight arsenicosis area have lower IQ than those who live in a non-arsenicosis area, and there may be a strong association between arsenic and children’s intelligence.
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References
World Health Organization. Guidelines for drinking water quality. v. 1: recommendations. http://www.who.int/water_sanitation_health/dwq/gdwq3/en/ (accessed on 03/Sep/2006)
México (2000) Modificación a la Norma Oficial Mexicana NOM-127-SSA1-1994. Salud ambiental, agua para uso y consumo humano. Límites permisibles de calidad y tratamientos a que se debe someterse el agua para su potabilización. Diario Oficial, Primera sección, p 48–54
Smedley PL, Kinniburgh DG (2002) A review of the source, behavior and distribution of arsenic in natural waters. Review. Appl Geochem 17:517–568
von Ehrenstein OS, Poddar S, Yuan Y, Mazumder DG, Eskenazi B, Basu A, Hira-Smith M, Ghosh N, Lahiri S, Haque R, Ghosh A, Kalman D, Das S, Smith AH (2007) Children’s intellectual function in relation to arsenic exposure. Epidemiology 18(1):44–51
NRC (2001) Subcommittee to update the 1999 Arsenic in drinking water report. Arsenic in Drinking Water 2001 Update 24–74
Rodriguez VM, Carrizales L, Mendoza MS et al (2002) Effects of sodium arsenite exposure on development and behavior in the rat. Neurotoxicol Teratol 24:743–750
Chattopadhyay S, Bhaumik S, Nag Chaudhury A et al (2002) Arsenic induced changes in growth development and apoptosis in neonatal and adult brain cells in vivo and in tissue culture. Toxicol Lett 128:73–84
Petitti DB (1994) Meta-analysis, decision analysis and cost-effectiveness analysis. Methods for quantitative synthesis in medicine. Oxford University Press, New York, pp 90–123
Breierova L, Choudhari M (1996) An introduction to sensitivity analysis. MIT Pr pp 41–107
Wang SX, Wang ZH, Cheng XT et al (2007) Arsenic and fluoride exposure in drinking water: children’s IQ and growth in Shanyin county, Shanxi province, China. Environ Health Perspect 115(4):643–647
Mei SZ, Liu AP, Li ZW et al (1996) The epidemic investigation reports of chronic arsenicosis in Mutouhu Village of Youqi of Mongolia. Zhong Guo Di Fang Bing Xue Za Zhi 15(4):237–240, [in Chinese]
Wang SX, Wang ZH, Cheng XT et al (2005) Investigation and evaluation on intelligence and growth of children in endemic fluorosis and arsenism areas. Zhong Guo Di Fang Bing Xue Za Zhi 24(2):179–182, [in Chinese]
Kang J, Jin Y, Cheng Y et al (2007) Effects of arsenic in drinking water on children’s intelligence. Wei Sheng Yan Jiu 36(3):347–349
Tseng CH (1999) Chronic arsenic intoxication in Asia: current perspectives. J Intern Med Taiwan 10:224–229
Niu S, Cao S, Shen E (1992) The status of arsenic poisoning in China. In: Abernathy CO, Calderon RL, Chappell WR (eds) Arsenic: exposure and health effects. Chapman & Hall, Boca Raton, pp 78–83
Calderon J, Navarro ME, Jimenez-Capdeville ME, Santos-Diaz MA, Golden A, Rodriguez-Leyva I et al (2001) Exposure to arsenic and lead and neuropsychological development in Mexican children. Environ Res 85(2):69–76
Wang L-F (1997) Endemic arsenism and blackfoot disease. Xinjiang Science and Technological Medical Publishing House, Xinjiang
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The authors are grateful to the support of Young Science and Technology Fund in Nanjing University of Traditional Chinese Medicine. The authors also appreciate the editorial board and the reviewers for their work on this paper.
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Dong, J., Su, SY. The Association Between Arsenic and Children’s Intelligence: A Meta-analysis. Biol Trace Elem Res 129, 88–93 (2009). https://doi.org/10.1007/s12011-008-8298-1
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DOI: https://doi.org/10.1007/s12011-008-8298-1