Original Articles

Smoking, Family History of Cancer, and Diabetes Mellitus Are Associated With the Age of Onset of Pancreatic Cancer in Japanese Patients

Mizuno, Suguru MD, PhD; Nakai, Yousuke MD, PhD; Isayama, Hiroyuki MD, PhD; Kawahata, Shuhei MD; Saito, Tomotaka MD; Takagi, Kaoru MD; Watanabe, Takeo MD; Uchino, Rie MD, PhD; Hamada, Tsuyoshi MD, PhD; Miyabayashi, Koji MD, PhD; Kogure, Hirofumi MD, PhD; Sasaki, Takashi MD, PhD; Yamamoto, Natsuyo MD, PhD; Sasahira, Naoki MD, PhD; Hirano, Kenji MD, PhD; Tsujino, Takeshi MD, PhD; Ijichi, Hideaki MD, PhD; Tateishi, Keisuke MD, PhD; Tada, Minoru MD, PhD; Koike, Kazuhiko MD, PhD

Author Information

From the Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Received for publication July 1, 2013; accepted April 2, 2014.

Reprints: Yousuke Nakai, MD, PhD, Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan (e-mail: [email protected]).

The authors declare no conflict of interest.

Pancreas 43(7):p 1014-1017, October 2014. | DOI: 10.1097/MPA.0000000000000158

Abstract

Objectives 

The aim of this study was to examine the association of risk factors including diabetes mellitus (DM) with the age of onset in Japanese pancreatic cancer (PC) patients.

Methods 

We retrospectively reviewed 688 PC patients diagnosed at our institute. We analyzed the association between the age of onset of PC and the following variables: sex, smoking, alcohol, DM, and a family history of cancer especially PC.

Results 

The mean age of PC diagnosis was 67.6 years. The onset of PC occurred earlier in current smokers (63.6 years old, P < 0.001) compared with past smokers (69.5 years old) and never smokers (68.6 years old). Patients with long-standing DM (>2 years) were older (70.5 years, P < 0.001) when diagnosed with PC than patients with new-onset DM (within 2 years) (66.9 years old) and patients without DM (66.7 years old). In the multivariate analysis, current smokers and a family history of cancer other than PC were associated with earlier onset. Conversely, long-standing DM was associated with later onset.

Conclusions 

In Japanese PC patients, current smokers and a family history of cancer other than PC were associated with a younger age of onset. Conversely, long-standing DM was associated with a later onset.

© 2014 by Lippincott Williams & Wilkins.

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