CIRCULATION AND HEMODYNAMICS: Edited by Matthew R. Weir and Roland C. Blantz

Impaired pressure natriuresis is associated with interstitial inflammation in salt-sensitive hypertension

Rodriguez-Iturbe, Bernardoa; Franco, Marthab; Johnson, Richard J.c

Author Information

aThe Renal Service, Hospital Universitario, Universidad del Zulia, Maracaibo, Venezuela

bDepartment of Nephrology, Instituto Nacional de Cardiologia I.Ch., Mexico City, Mexico

cDivision of Renal Diseases and Hypertension, University of Colorado, Denver, Denver, Colorado, USA

Correspondence to Bernardo Rodriguez-Iturbe, Servicio de Nefrología, Hospital Universitario, Avenue Goajira s/n, Maracaibo, Venezuela. Tel: +58 261 7519610; e-mail: [email protected]

Current Opinion in Nephrology and Hypertension 22(1):p 37-44, January 2013. | DOI: 10.1097/MNH.0b013e32835b3d54

Abstract

Purpose of review 

Impairment of the pressure natriuresis relationship is a central event in the pathogenesis of hypertension. Renal tubulointerstitial inflammation results in salt-sensitive hypertension and, until recently, the changes in pressure natriuresis induced by renal inflammation received little attention.

Recent findings 

Oxidative stress and increased intrarenal angiotensin II activity, in association with rarefaction and loss of peritubular vascular network, may be involved in the inflammation-induced blunting of the natriuresis resulting from increments in renal perfusion pressure.

Summary 

Here, we review the mechanisms for the impairment in pressure natriuresis resulting from renal tubulointerstitial inflammation in reference to the normal physiologic mechanisms involved in this response.

© 2013 Lippincott Williams & Wilkins, Inc.

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