Abstract

The antioxidative activities of (−)-epigallocatechin gallate (EGCg) metabolites degraded by rat intestinal flora were investigated by a flow injection analysis coupled to an on-line antioxidant detection system with the 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation. All of the metabolites were found to have antioxidative activity, suggesting that the EGCg metabolites may show antioxidative activity in the body.

Reference

1) Nanjo F, Goto K, Seto R, Suzuki M, Sakai M, and Hara Y, Free Radic. Biol. Med., 21, 895–902 (1996).

2) Nanjo F, Mori M, Goto K, and Hara Y, Biosci. Biotechnol. Biochem., 63, 1621–1623 (1999).

3) Kohri T, Matsumoto N, Yamakawa M, Suzuki M, Nanjo F, Hara Y, and Oku N, J. Agric. Food Chem., 49, 4102–4112 (2001).

4) Li C, Lee M-J, Sheng S, Meng X, Prabhu S, Winnik B, Huang B, Chung JY, Yan S, Ho C-T, and Yang CS, Chem. Res. Toxicol., 13, 177–184 (2000).

5) Lambert JD, Rice JE, Hong J, Hou Z, and Yang CS, Bioorg. Med. Chem. Lett., 15, 873–876 (2005).

6) Unno T, Tamemoto K, Yayabe F, and Kakuda T, J. Agric. Food Chem., 51 6893–6898 (2003).

7) Takagaki A, Arai D, Ishikawa S, and Nanjo F, Proceedings in the 3rd International Conference on O-CHA (Tea) Culture and Science, HB-P-501 (2007).

8) Takagaki A and Nanjo F, J. Agric. Food Chem., 58, 1313–1321 (2010).

9) Kohri T, Suzuki M, and Nanjo F, J. Agric. Food Chem., 51, 5561–5566 (2003).

10) Hamada M, Furuno A, Nakano S, Kishimoto T, and Nakajima N, Synthesis, 9, 1512–1520 (2010).

11) Stewart AJ, Mullen W, and Crozier A, Mol. Nutr. Food Res., 49, 52–60 (2005).

12) Pannala AS, Chan TS, O’Brien PJ, and Rice-Evans CA, Biochem. Biophys. Res. Commun., 282, 1161–1168 (2001).

13) Senthil KV, Arulmathi K, Srividhya R, and Kalaiselvi P, Exp. Gerontol., 43, 176–183 (2008).

14) Yoshino K, Tomita I, Sano M, Oguni I, Hara Y, and Nakano M, Age, 17, 79–85 (1994).

15) Nanjo F, Honda M, Okushio K, Matsumoto N, Ishigaki F, Ishigami T, and Hara Y, Biol. Pharm. Bull., 16, 1156–1159 (1993).

16) Lee M-J, Maliakal P, Chen L, Meng X, Bondoc FY, Prabhu S, Lambert G, Mohr S, and Yang CS, Cancer Epidemiol. Biomarkers Prev., 11, 1025–1032 (2002).

17) Li C, Meng X, Winnik B, Lee M-J, Lu H, Sheng S, Buckley B, and Yang CS, Chem. Res. Toxicol., 14, 702–707 (2001).

18) Feng WF, Curr. Drug Metab., 7, 755–809 (2006).

This content is only available as a PDF.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)